Product Description
Zetomipzomib (KZR-616) is a first-in-class, selective immunoproteasome inhibitor for a range of autoimmune diseases. Immunoproteasomes play an important role in regulating the normal function of the immune system and when inhibited, multiple pathways involved in inflammatory cytokine production and immune effector cell activity – including macrophages, B cells and T cells – are also inhibited. Since the pathways regulated by immunoproteasomes are involved in the pathogenesis of many autoimmune diseases, zetomipzomib offers a “pipeline in a drug” approach, with the potential to be a treatment option for a broad range of autoimmune conditions. (Sourced from: https://www.kezarlifesciences.com/pipeline/zetomipzomib)
Mechanisms of Action: Proteasome Inhibitor
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Subcutaneous,Intravenous
FDA Designation: Orphan Drug - Dermatomyositis|Myositis|Polymyositis *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Kezar Life Sciences
Company Location: SOUTH SAN FRANCISCO CA 94080
Company CEO: John Fowler
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic: Argentina, Australia, Brazil, China, Colombia, Croatia, Czech Republic, France, Germany, Greece, Guatemala, India, Italy, Korea, Malaysia, Mexico, Peru, Philippines, Poland, Portugal, Puerto Rico, Russia, Serbia, South Africa, Spain, Taiwan, Ukraine, United Kingdom, United States
Active Clinical Trial Count: 9
Highest Development Phases
Phase 2: Dermatomyositis|Hepatitis A|Hepatitis, Autoimmune|Lupus Erythematosus, Systemic|Lupus Nephritis|Polymyositis
Phase 1: Arthritis, Rheumatoid
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
---|---|---|---|---|---|
PALIZADE | P2 |
Suspended |
Lupus Nephritis |
2026-05-01 |
|
KZR-616-202 | P2 |
Unknown Status |
Lupus Nephritis |
2026-04-30 |
|
PORTOLA | P2 |
Active, not recruiting |
Hepatitis A|Hepatitis, Autoimmune |
2025-02-01 |
|
2020-004382-39 | P2 |
Active, not recruiting |
Polymyositis|Dermatomyositis |
2023-04-02 |