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ZEN-003694

Alternative Names: zen-003694, zen003694, zen 003694, zen-3694, zen 3694, zen3694
Latest Update: 2024-08-21
Latest Update Note: Clinical Trial Update

Product Description

ZEN-3694 is a novel BETi that inhibits proliferation of several cancer cell lines, and synergizes with various anti-cancer agents. (Sourced from: https://www.zenithepigenetics.com/upload/media_element/36/01/2015-aacr-eortc-poster.pdf)

Mechanisms of Action: BET Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Zenith Epigenetics
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for ZEN-003694

Countries in Clinic: China, United States

Active Clinical Trial Count: 9

Highest Development Phases

Phase 2: Adenocarcinoma|Fallopian Tube Cancer|Lung Cancer|Ovarian Cancer|Peritoneal Cancer|Prostate Cancer|Small Cell Lung Cancer|Triple Negative Breast Cancer

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
HCC 21-091

P2

Recruiting

Fallopian Tube Cancer|Peritoneal Cancer|Ovarian Cancer

2029-12-01

NCI-2020-04495

P2

Recruiting

Small Cell Lung Cancer|Prostate Cancer|Adenocarcinoma

2027-04-30

HCC 22-142

P1

Recruiting

Ovarian Cancer

2026-12-31

NCT05607108

P2

Recruiting

Lung Cancer

2025-11-01

Recent News Events

Date

Type

Title

03/18/2024

PubMed

 An LC-MS/MS method for determination of the bromodomain inhibitor ZEN-3694 and its metabolite ZEN-3791 in human plasma.

06/01/2023

News Article

 Zenith Epigenetics Reports Advancement of ZEN-3694 in NUT Carcinoma

07/25/2022

News Article

 Combination Cancer Immunotherapy Market Opportunity and Clinical Trials Insights, 2028

07/06/2022

News Article

 Zenith Epigenetics Announces Start of Several National Cancer Institute (NCI)-Sponsored Oncology Clinical Trials

06/23/2022

News Article

 The Worldwide Combination Cancer Immunotherapy Industry is Expected to Surpass $15 Billion by 2028

06/01/2022

PubMed

 Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer.

10/15/2020

PubMed

 A Phase Ib/IIa Study of the Pan-BET Inhibitor ZEN-3694 in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer.

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