Drug Search Results

Vimirogant

Alternative Names: vimirogant, vtp-43742, vtp43742, vtp 43742
Latest Update: 2022-08-01
Latest Update Note: PubMed Publication

Product Description

Inhibitor of RORC (Sourced from: https://www.chemicalprobes.org/vimirogant)

Mechanisms of Action: RORG Antagonist

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: AbbVie
Company Location: NORTH CHICAGO IL 60064
Company CEO: Richard A. Gonzalez
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Vimirogant

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Psoriasis

Trial	Phase	Trial Status	Disease	Primary Completion Date	Probability of Success
VTP-43742-002-1	P1	Completed	Psoriasis	2016-03-08	22%
VTP-43742-002	P2	Completed	Psoriasis	2016-03-01	39%

Recent News Events

Date	Type	Title
08/01/2022	PubMed	Nuclear receptor RORγ inverse agonists/antagonists display tissue- and gene-context selectivity through distinct activities in altering chromatin accessibility and master regulator SREBP2 occupancy.
02/01/2022	PubMed	Discovery of N-(2-benzyl-4-oxochroman-7-yl)-2-(5-(ethylsulfonyl) pyridin-2-yl) acetamide (b12) as a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist.
10/28/2021	PubMed	Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity.

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