Product Description
Mechanisms of Action: CGRP Antagonist
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Merck
Company Location: KENILWORTH NJ 07033
Company CEO: Robert M. Davis
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Highest Development Phases
Phase 3: Migraine Disorders|Ischemic Attack, Transient|Ischemic Stroke|Peripheral Arterial Disease|Peripheral Vascular Diseases|Cerebrovascular Disorders|Coronary Artery Disease
Phase 2: Migraine Disorders
Phase 1: Migraine Disorders|Angina Pectoris|Coronary Artery Disease|Myocardial Ischemia|Angina, Stable
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| MK-0974-067 | P1 |
Completed |
Migraine Disorders |
2011-07-26 |
|
| MK0974-065 | P3 |
Completed |
Migraine Disorders |
2011-04-08 |
|
| MK-0974-065 | P3 |
Completed |
Migraine Disorders |
2011-04-08 |
|
| MK-0974-034 | P3 |
Completed |
Peripheral Arterial Disease|Ischemic Stroke|Migraine Disorders|Ischemic Attack, Transient|Peripheral Vascular Diseases|Cerebrovascular Disorders |
2009-09-02 |
|
| MK-0974-046 | P2 |
Completed |
Migraine Disorders |
2009-08-24 |
|
| Combination Dosing | P2 |
Completed |
Migraine Disorders |
2009-08-24 |
|
| NCT00797667 | P2 |
Terminated |
Migraine Disorders |
2009-05-20 |
|
| Acute Treatment of Multiple Migraines With or Without Aura in Adults | P3 |
Completed |
Migraine Disorders |
2009-03-27 |
|
| Safety and Efficacy of MK-0974 in the Treatment of Acute Migraine in Patients | P3 |
Completed |
Migraine Disorders|Coronary Artery Disease |
2009-03-25 |
|
| MK-0974-031 | P3 |
Completed |
Migraine Disorders |
2009-03-25 |
|
| MK-0974-014 | P1 |
Completed |
Coronary Artery Disease|Myocardial Ischemia|Angina Pectoris|Angina, Stable |
2009-02-28 |
|
| Long Term Safety Study | P3 |
Completed |
Migraine Disorders |
2009-01-23 |
|
| MK-0974-012 | P3 |
Completed |
Migraine Disorders |
2009-01-22 |
|
| MK0974-045 | P1 |
Completed |
Migraine Disorders |
2008-05-01 |
|
| MK0974-042 | P1 |
Completed |
Migraine Disorders |
2008-05-01 |
|
| 2006-006187-35 | P3 |
Completed |
Migraine Disorders |
2008-01-11 |
|
| NCT00432237 | P3 |
Completed |
Migraine Disorders |
2007-12-01 |
|
| NCT01209741 | P1 |
Completed |
Migraine Disorders |
2007-11-01 |
|
| MK-0974 Pivotal Study 1 - worldwide (with active comparator) | P3 |
Completed |
Migraine Disorders |
2007-10-02 |
|
| MK-0974-011 | P3 |
Completed |
Migraine Disorders |
2007-10-02 |
|
| MK0974-004 | P2 |
Completed |
Migraine Disorders |
2006-05-01 |