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TAK-960

Alternative Names: tak-960, tak960, tak 960
Latest Update: 2014-03-03
Latest Update Note: Clinical Trial Update

Product Description

TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens. TAK-960 [4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl) benzamide] is a novel, investigational, orally bioavailable, potent, and selective PLK1 inhibitor that has shown activity in several tumor cell lines, including those that express multidrug-resistant protein 1 (MDR1). (Sourced from: https://pubmed.ncbi.nlm.nih.gov/22188812/)

Mechanisms of Action: PLK1 Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Takeda
Company Location: TOKYO M0 103-8668
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for TAK-960

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 1: Oncology Unspecified|Oncology Hematological Unspecified

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
C22001

P1

Terminated

Oncology Hematological Unspecified|Oncology Unspecified

2012-10-01

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