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Squalamine

Alternative Names: squalamine
Latest Update: 2024-01-10
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: Angiogenesis Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral,Ophthalmic

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Genaera
Company Location: PLYMOUTH MEETING PA 19462
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Squalamine

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Wet Macular Degeneration|Choroidal Neovascularization|Macular Degeneration

Phase 2: Wet Macular Degeneration|Diabetic Retinopathy|Macular Degeneration|Retinal Neovascularization|Prostate Cancer|Macular Edema|Choroidal Neovascularization|Ovarian Cancer|Retinal Vein Occlusion

Phase 1: Amyotrophic Lateral Sclerosis

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
ACTRN12619000375156

P1

Completed

Amyotrophic Lateral Sclerosis

2018-11-06

MAKO

P3

Unknown status

Macular Degeneration

2017-12-01

OHR-1501

P2

Withdrawn

Wet Macular Degeneration

2016-04-01

Ohr-005

P2

Withdrawn

Diabetic Retinopathy|Macular Edema

2015-09-01

Recent News Events

Date

Type

Title

01/10/2024

PubMed

 Squalamine reverses age-associated changes of firing patterns of myenteric sensory neurons and vagal fibres.

12/20/2023

PubMed

 Antibiofilm and Antivirulence Properties of 6-Polyaminosteroid Derivatives against Antibiotic-Resistant Bacteria.

11/13/2023

PubMed

 Ceragenins and Ceragenin-Based Core-Shell Nanosystems as New Antibacterial Agents against Gram-Negative Rods Causing Nosocomial Infections.

05/31/2023

News Article

 Enterin announces FDA acceptance of an investigator sponsored IND to treat a patient with prodromal multisystem atrophy (MSA) with ENT-01

11/19/2021

News Article

 Enterin Announces Publication of Exciting Discoveries About the Enterin Nervous System

11/19/2021

News Article

 Enterin Announces Publication of Exciting Discoveries About the Enterin Nervous System

11/19/2021

News Article

 Enterin Announces That the Enteric Nervous System Directly Impacts Neuropsychiatric Symptoms

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