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Sarcolysin

Alternative Names: sarcolysin
Latest Update: 2024-07-11
Latest Update Note: Clinical Trial Update

Product Description

St. Jude Children's Research Hospital is developing sarcolysin as an anticancer medicine. It is a type of chemotherapy that works by slowing or stopping growth of cancer cells. It may be used to help prepare patients for hematopoietic cell transplant. (Sourced from: https://together.stjude.org/en-us/diagnosis-treatment/medicines-list/melphalan.html)

Mechanisms of Action: Alkylating Agent

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: India | Russia

Approved Indications: None

Known Adverse Events: None

Company: City of Hope Medical Center
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Sarcolysin

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Neuroblastoma|Myelodysplastic Syndrome|Acute Myeloid Leukemia|Acute Lymphoid Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Preleukemia|Ganglioneuroblastoma

Phase 2: Crohn Disease|Leukemia|Lymphoma|Preleukemia|Chronic Myelomonocytic Leukemia|Acute Myelomonocytic Leukemia|Anemia, Aplastic|Multiple Myeloma|Acute Myeloid Leukemia|Myelodysplastic Syndrome|Anemia, Refractory, with Excess of Blasts|Chronic Myeloid Leukemia|Acute Monocytic Leukemia|Paroxysmal Hemoglobinuria|Juvenile Myelomonocytic Leukemia,|Graft vs Host Disease|Leukemia, Plasma Cell|Lymphoma, B-Cell|B-Cell Leukemia|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Myelodysplastic-Myeloproliferative Diseases|Myeloid, Accelerated Leukemia|Neuroblastoma|Chronic Lymphoid Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Biphenotypic Acute Leukemia|Lymphoma, Non-Hodgkin|Acute Lymphoid Leukemia|Myeloproliferative Disorders|Large-Cell Immunoblastic Lymphoma|Prolymphocytic T-Cell Leukemia|Hodgkin Lymphoma|Follicular Lymphoma|Blast Crisis|HIV Infections|Burkitt Lymphoma|Prolymphocytic Leukemia|Sarcoma, Myeloid|Plasmablastic Lymphoma|Lymphocytic Chronic B-Cell Leukemia|Waldenstrom Macroglobulinemia|T-Cell Lymphoma|Mantle-Cell Lymphoma|Prolymphocytic B-Cell Leukemia|Melanoma|Histiocytosis, Langerhans-Cell

Phase 1: Blast Crisis|Lymphoma, Non-Hodgkin|Juvenile Myelomonocytic Leukemia,|Acute Myelomonocytic Leukemia|Lymphoma, B-Cell|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Chronic Myeloid Leukemia|Myeloproliferative Disorders|Acute Monocytic Leukemia|Lymphocytic Chronic B-Cell Leukemia|Anemia, Aplastic|Acute Lymphoid Leukemia|Acute Myeloid Leukemia|Multiple Myeloma|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Chronic Lymphoid Leukemia|Chronic Myelomonocytic Leukemia|Myelodysplastic Syndrome|Leukemia, Plasma Cell|Preleukemia|Sarcoma, Ewing|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|Clear Cell Adenocarcinoma|Gastrointestinal Cancer|Wilms Tumor|Clear Cell Sarcoma|Renal Cell Carcinoma|Rhabdomyosarcoma|Neuroblastoma|Lymphoma|Biphenotypic Acute Leukemia|Melanoma|Rhabdoid Tumor|Adenomyoepithelioma|Myeloid, Accelerated Leukemia

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

NCI-2023-08530

P3

Recruiting

Ganglioneuroblastoma

2029-12-31

ASCT2031

P3

Recruiting

Preleukemia|Acute Lymphoid Leukemia|Acute Myeloid Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Myelodysplastic Syndrome

2027-12-01

PRO11090340

P2

Recruiting

Crohn Disease

2025-12-01

NCI-2016-00584

P2

Recruiting

Precursor Cell Lymphoblastic Leukemia-Lymphoma|Myeloid, Accelerated Leukemia|Acute Monocytic Leukemia|Chronic Myelomonocytic Leukemia|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Biphenotypic Acute Leukemia|Acute Myeloid Leukemia|Lymphoma, B-Cell|Acute Myelomonocytic Leukemia|Acute Lymphoid Leukemia|Leukemia, Plasma Cell|Myeloproliferative Disorders|Chronic Myeloid Leukemia|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|B-Cell Leukemia|Myelodysplastic Syndrome|Chronic Lymphoid Leukemia|Anemia, Refractory, with Excess of Blasts|Multiple Myeloma|Juvenile Myelomonocytic Leukemia,|Preleukemia|Lymphoma, Non-Hodgkin|Myelodysplastic-Myeloproliferative Diseases

2025-05-31

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