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SAL-003

Alternative Names: sal-003, sal 003, sal003
Latest Update: 2024-01-17
Latest Update Note: PubMed Publication

Product Description

Center for Clinical Pharmacology, the Third Xiangya Hospital, Central South University is developing SAL-003 as a treatment for intervertebral disc degeneration. (Sourced from: https://pubmed.ncbi.nlm.nih.gov/36744257/)

Mechanisms of Action: eiF2A Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Subcutaneous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Center for Clinical Pharmacology, the Third Xiangya Hospital, Central South University
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for SAL-003

Countries in Clinic: China

Active Clinical Trial Count: 2

Highest Development Phases

Phase 2: Hypercholesterolemia|Hyperlipidemia

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
CTR20212013

P1

Not yet recruiting

Hyperlipidemia|Hypercholesterolemia

None

CTR20230897

P2

Not yet recruiting

Hypercholesterolemia|Hyperlipidemia

None

Recent News Events

Date

Type

Title

01/17/2024

PubMed

 Model-Informed Dose Selection for a Novel Human Immunoglobulin G4 Derived Monoclonal Antibody Targeting Proprotein Convertase Kwashiorkor Type 9: Insights from Population Pharmacokinetics-Pharmacodynamics and Systems Pharmacology.

01/20/2023

PubMed

 Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats.

07/08/2022

PubMed

 Integrated Stress Response Regulation of Corneal Epithelial Cell Motility and Cytokine Production.

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