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Rolapitant

Alternative Names: rolapitant, sch 619734, varubi
Latest Update: 2023-09-26
Latest Update Note: News Article

Product Description

Rolapitant is a highly selective neurokinin-1 (NK-1) receptor antagonist with very good oral activity, central nervous system penetration and a long (180-hour) plasma half-life.  (Sourced from: https://pubmed.ncbi.nlm.nih.gov/28393710/)

Mechanisms of Action: NK1 Antagonist

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Approved

Approved Countries: Belgium | European Medicines Agency | France | Germany | Hungary | Ireland | Italy | Lithuania | Poland | Portugal | Spain | Sweden | United Kingdom | United States

Approved Indications: Oncology Unspecified

Known Adverse Events: Dizziness | Neutropenia | Hiccup

Company: GlaxoSmithKline
Company Location: BRENTFORD MIDDLESEX X0 TW8 9GS
Company CEO: Emma Walmsley
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Rolapitant

Countries in Clinic: China

Active Clinical Trial Count: 1

Highest Development Phases

Phase 1: Healthy Volunteers

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

CTR20212383

P1

Not yet recruiting

Healthy Volunteers

None

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