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Pinometostat

Alternative Names: pinometostat, epz-5676
Latest Update: 2024-06-11
Latest Update Note: Clinical Trial Update

Product Description

Mechanisms of Action: DOT1L Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Epizyme
Company Location: CAMBRIDGE MA 02139
Company CEO: Grant Bogle
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Pinometostat

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Acute Myeloid Leukemia

Phase 1: Precursor Cell Lymphoblastic Leukemia-Lymphoma|Acute Lymphoid Leukemia|Acute Myeloid Leukemia|Preleukemia|Myeloproliferative Disorders|Myelodysplastic Syndrome

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
NCI-2018-02349

P2

Terminated

Acute Myeloid Leukemia

2022-11-14

NCI-2018-02128

P2

Completed

Acute Myeloid Leukemia

2020-12-08

EPZ-5676-12-002

P1

Completed

Precursor Cell Lymphoblastic Leukemia-Lymphoma|Acute Lymphoid Leukemia|Acute Myeloid Leukemia

2016-05-01

34%
EPZ-5676-12-001

P1

Completed

Myelodysplastic Syndrome|Myeloproliferative Disorders|Preleukemia|Acute Myeloid Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Acute Lymphoid Leukemia

2015-11-01

34%

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