Product Description
Mechanisms of Action: Akt Inhibitor, PI3K Modulator
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Company: AEterna Zentaris
Company Location:
Company Founding Year: None
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Recent & Upcoming Milestones
Highest Development Phases
Phase 3: Multiple Myeloma|Colorectal Cancer
Phase 2: Head and Neck Cancer|Non-Small-Cell Lung Cancer|Colorectal Cancer|Adenocarcinoma|Pancreatic Cancer|Renal Cell Carcinoma|Multiple Myeloma|Prostate Cancer|Glioma|Chondrosarcoma|Brain Cancer|Cervical Cancer|Ovarian Cancer|Sarcoma|Gastrointestinal Stromal Tumors|Waldenstrom Macroglobulinemia|Lymphoma|Breast Cancer|Endometrial Cancer|Melanoma|Kidney Cancer|Lymphocytic Chronic B-Cell Leukemia|Alveolar Soft Part Sarcoma|Glioblastoma|Chronic Lymphoid Leukemia|Lymphoma, B-Cell|Leukemia|Oligodendroglioma|Gliosarcoma|Astrocytoma
Phase 1: Myeloproliferative Disorders|Lymphoma|Renal Cell Carcinoma|Kidney Cancer|Chronic Lymphoid Leukemia|Acute Megakaryoblastic Leukemia|Acute Promyelocytic Leukemia|Chronic Myelomonocytic Leukemia|Chronic Myeloid Leukemia|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Acute Myelomonocytic Leukemia|Myelodysplastic Syndrome|Acute Myeloid Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Preleukemia|Myelodysplastic-Myeloproliferative Diseases|Diarrhea|Adult T-Cell Leukemia-Lymphoma|Acute Monocytic Leukemia|Liver Cancer|Myeloid, Accelerated Leukemia|Acute Lymphoid Leukemia|Precursor T-Cell Lymphoblastic Leukemia-Lymphoma|Acute Erythroblastic Leukemia|Heart Failure, Chronic|Angina, Stable|Hepatitis C, Chronic|Hypertrophy, Left Ventricular|Hypokalemia|Blast Crisis|Brain Cancer|Heart Failure, Acute|Angina, Unstable|Prostate Cancer|Glioblastoma|Pregnancy Outcomes|Angina Pectoris|Neuromyelitis Optica|Astrocytoma|Oligodendroglioma|Neuroblastoma|Myocardial Infarction|Hepatitis B, Chronic|Surgical Wound Infection|HIV Infections|Contraception|Torsades de Pointes|Ovarian Cancer|Oncology Solid Tumor Unspecified|Multiple Myeloma|Colorectal Cancer
Trial ID |
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
Latest Trial Update Date |
Data Updated |
|---|---|---|---|---|---|---|---|---|
NCT00847366 |
Perifosine 534 | N/A |
Completed |
Non-Small-Cell Lung Cancer|Sarcoma|Multiple Myeloma|Breast Cancer |
2012-12-01 |
2025-02-07 |
Primary Endpoints|Treatments |
|
NCT02238496 |
AAAM3801 | P1 |
Completed |
Brain Cancer|Oligodendroglioma|Astrocytoma|Glioblastoma |
2017-10-27 |
88% |
2023-05-26 |
Primary Endpoints|Treatments |
NCT00776867 |
NCT00776867 | P1 |
Completed |
Oncology Solid Tumor Unspecified |
2017-07-01 |
2019-03-18 |
||
NCT01049841 |
NCT01049841 | P1 |
Completed |
Oncology Solid Tumor Unspecified |
2017-03-01 |
2025-08-27 |
Primary Endpoints|Treatments |
|
JapicCTI-132130 |
JapicCTI-132130 | P1 |
Completed |
Neuroblastoma |
2015-11-01 |
|||
NCT01224730 |
Protocol 147 | P1 |
Completed |
Heart Failure, Acute|Torsades de Pointes|Angina Pectoris|Hepatitis B, Chronic|Surgical Wound Infection|Hepatitis C, Chronic|Angina, Unstable|Contraception|Heart Failure, Chronic|Angina, Stable|Myocardial Infarction|HIV Infections|Neuromyelitis Optica|Pregnancy Outcomes|Hypokalemia|Hypertrophy, Left Ventricular |
2013-11-04 |
2019-03-19 |
Treatments |
|
JapicCTI-121748 |
JapicCTI-121748 | P1 |
Terminated |
Multiple Myeloma |
2012-12-31 |
|||
NCT00415064 |
Perifosine 127 | P1 |
Completed |
Multiple Myeloma |
2012-07-01 |
2025-08-27 |
Primary Endpoints|Treatments |
|
NCT00301938 |
NCI-2009-00149 | P1 |
Completed |
Chronic Myeloid Leukemia|Acute Myeloid Leukemia|Acute Myelomonocytic Leukemia|Myelodysplastic-Myeloproliferative Diseases|Chronic Lymphoid Leukemia|Acute Megakaryoblastic Leukemia|Acute Lymphoid Leukemia|Myeloproliferative Disorders|Myeloid, Accelerated Leukemia|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Preleukemia|Myelodysplastic Syndrome|Acute Monocytic Leukemia|Acute Erythroblastic Leukemia|Precursor T-Cell Lymphoblastic Leukemia-Lymphoma|Acute Promyelocytic Leukemia|Chronic Myelomonocytic Leukemia|Adult T-Cell Leukemia-Lymphoma|Blast Crisis |
2012-05-01 |
2019-03-21 |
||
NCT00431054 |
Pharmacodynamic Trial | P1 |
Completed |
Ovarian Cancer |
2012-05-01 |
2019-03-21 |
Treatments |
|
NCT00398814 |
Perifosine 124 | P1 |
Completed |
Renal Cell Carcinoma|Kidney Cancer |
2011-09-01 |
2019-03-21 |
Treatments |
|
NCT01048580 |
Perifosine 141 | P1 |
Completed |
Colorectal Cancer |
2011-05-01 |
2019-03-19 |
Treatments |
|
NCT00590954 |
NCT00590954 | P2 |
Completed |
Glioma|Brain Cancer |
2019-11-11 |
2025-08-27 |
Primary Endpoints|Treatments |
|
NCT01051557 |
NCI-2011-01409 | P2 |
Completed |
Glioblastoma|Gliosarcoma|Oligodendroglioma|Astrocytoma |
2018-11-16 |
2021-07-20 |
||
JapicCTI-132287 |
JapicCTI-132287 | P2 |
Completed |
Ovarian Cancer|Cervical Cancer |
2015-11-30 |
|||
JapicCTI-111712 |
JapicCTI-111712 | P2 |
Terminated |
Colorectal Cancer |
2013-07-31 |
|||
NCT00873457 |
Pro00015060 | P2 |
Completed |
Chronic Lymphoid Leukemia|Lymphoma, B-Cell|Lymphocytic Chronic B-Cell Leukemia |
2011-10-01 |
2019-03-18 |
Treatments |
|
NCT00398710 |
Perifosine 221 | P2 |
Completed |
Waldenstrom Macroglobulinemia |
2011-08-01 |
2019-03-21 |
Treatments |
|
NCT00389077 |
Perifosine 207 | P2 |
Completed |
Lymphoma |
2011-07-01 |
2019-03-21 |
Treatments |
|
NCT00498966 |
Perifosine 231 | P2 |
Completed |
Kidney Cancer |
2011-07-01 |
2019-03-21 |
Treatments |
|
NCT00401388 |
Perifosine 214 | P2 |
Completed |
Chondrosarcoma|Alveolar Soft Part Sarcoma |
2011-01-01 |
2019-03-22 |
Treatments |
|
NCT00399789 |
Perifosine 201 | P2 |
Completed |
Non-Small-Cell Lung Cancer |
2010-12-01 |
2019-03-21 |
Treatments |
|
2010-018893-19 |
2010-018893-19 | P3 |
Terminated |
Multiple Myeloma |
2013-03-11 |
2022-03-13 |
Treatments |
|
NCT01002248 |
Perifosine 339 | P3 |
Terminated |
Multiple Myeloma |
2013-03-01 |
2025-08-27 |
Primary Endpoints|Treatments |
|
NCT01097018 |
X-PECT | P3 |
Completed |
Colorectal Cancer |
2012-04-01 |
2019-03-19 |
Treatments |
