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Zidesamtinib

Alternative Names: Zidesamtinib, nvl-520, nvl 520, nvl520, nuv-520, nuv 520, nuv520
Latest Update: 2024-09-09
Latest Update Note: News Article

Product Description

NVL-520 is being developed by Nuvalent for the treatment of Locally Advanced Solid Tumor and Metastatic Solid Tumor. (Sourced from: https://clinicaltrials.gov/ct2/show/NCT05118789?term=NVL-520&draw=2&rank=1)

Mechanisms of Action: ROS1 Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: Breakthrough Therapy - *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Nuvalent
Company Location: CAMBRIDGE MA 02142
Company CEO: James R. Porter
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Zidesamtinib

Countries in Clinic: Australia, Belgium, Canada, France, Germany, Italy, Netherlands, Singapore, South Korea, Spain, Taiwan, United Kingdom, United States

Active Clinical Trial Count: 4

Highest Development Phases

Phase 2: Non-Small-Cell Lung Cancer|Small Cell Lung Cancer

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

NVL-520

P2

Unknown Status

Small Cell Lung Cancer|Non-Small-Cell Lung Cancer

2025-12-21

ARROS-1

P2

Recruiting

Small Cell Lung Cancer|Non-Small-Cell Lung Cancer

2025-10-31

jRCT2031230693

P2

Recruiting

Non-Small-Cell Lung Cancer|Small Cell Lung Cancer

2025-10-31

2021-002477-26

P2

Active, not recruiting

Non-Small-Cell Lung Cancer

2025-09-25

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