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Metoprolol

Alternative Names: metoprolol, toprol, lopressor, betaloc, seloken, toprol-xl, selo-zok, toprol xl, metoprololsuccinat, kapspargo sprinkle, kapspargo, dutoprol, lopressidone
Latest Update: 2024-02-15
Latest Update Note: News Article

Product Description

Metoprolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks or strokes. These problems may be less likely to occur if blood pressure is controlled. (Sourced from: https://www.mayoclinic.org/drugs-supplements/metoprolol-oral-route/description/drg-20071141#:~:text=Metoprolol%20is%20used%20alone%20or,arteries%20may%20not%20function%20properly.)

Mechanisms of Action: ADRB1 Blocker

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Approved

Approved Countries: Algeria | Argentina | Australia | Austria | Bangladesh | Belgium | Bosnia | Brazil | Bulgaria | Canada | Chile | China | Colombia | Croatia | Cyprus | Czech | Denmark | Dominican Republic | Ecuador | Egypt | Estonia | Finland | France | Germany | Greece | Hong Kong | Hungary | Iceland | India | Indonesia | Ireland | Israel | Italy | Jordan | Korea | Latvia | Lebanon | Lithuania | Luxembourg | Malaysia | Malta | Mexico | Morocco | Netherlands | New Zealand | Norway | Pakistan | Peru | Philippines | Poland | Portugal | Romania | Russia | Saudi Arabia | Serbia | Singapore | Slovakia | Slovenia | South Africa | Spain | Sri Lanka | Sweden | Switzerland | Taiwan | Thailand | Tunisia | Turkey | Ukraine | United Arab Emirates | United Kingdom | United States | Uruguay | Venezuela | Vietnam

Approved Indications: Myocardial Infarction | Heart Block | Heart Failure | Myocardial Infarction | Hypertension | Stroke | Angina Pectoris

Known Adverse Events: Bradycardia | Hypotension | Dizziness | Pruritus | Depressive Disorder | Diarrhea

Company: AstraZeneca
Company Location: CAMBRIDGE X0 CB2 0AA
Company CEO: Pascal Soriot
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Metoprolol

Countries in Clinic: Australia, Norway, Spain, United States

Active Clinical Trial Count: 5

Highest Development Phases

Phase 3: Acute Lung Injury|Acute Respiratory Distress Syndrome|Cardiac Arrest|Cardiac Arrhythmias|Cardiomyopathies|Cardiomyopathy, Hypertrophic|Mitral Valve Prolapse|Respiratory Distress Syndrome, Newborn

Phase 2: Autism Spectrum Disorder

Phase 1: HIV Infections

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

FLECAPRO

P3

Recruiting

Mitral Valve Prolapse|Cardiac Arrest|Cardiac Arrhythmias

2026-02-01

MAIDEN

P3

Not yet recruiting

Acute Lung Injury|Acute Respiratory Distress Syndrome|Respiratory Distress Syndrome, Newborn

2025-09-01

MAPLE-HCM

P3

Recruiting

Cardiomyopathy, Hypertrophic|Cardiomyopathies

2025-07-01

66%

2006-7041-83/hah

P2

Not yet recruiting

Autism Spectrum Disorder

2021-07-16

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