Product Description
Metoprolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks or strokes. These problems may be less likely to occur if blood pressure is controlled. (Sourced from: https://www.mayoclinic.org/drugs-supplements/metoprolol-oral-route/description/drg-20071141#:~:text=Metoprolol%20is%20used%20alone%20or,arteries%20may%20not%20function%20properly.)
Mechanisms of Action: ADRB1 Blocker
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: None *
Approval Status: Approved
Approved Countries: Algeria | Argentina | Australia | Austria | Bangladesh | Belgium | Bosnia | Brazil | Bulgaria | Canada | Chile | China | Colombia | Croatia | Cyprus | Czech | Denmark | Dominican Republic | Ecuador | Egypt | Estonia | Finland | France | Germany | Greece | Hong Kong | Hungary | Iceland | India | Indonesia | Ireland | Israel | Italy | Jordan | Korea | Latvia | Lebanon | Lithuania | Luxembourg | Malaysia | Malta | Mexico | Morocco | Netherlands | New Zealand | Norway | Pakistan | Peru | Philippines | Poland | Portugal | Romania | Russia | Saudi Arabia | Serbia | Singapore | Slovakia | Slovenia | South Africa | Spain | Sri Lanka | Sweden | Switzerland | Taiwan | Thailand | Tunisia | Turkey | Ukraine | United Arab Emirates | United Kingdom | United States | Uruguay | Venezuela | Vietnam
Approved Indications: Myocardial Infarction | Heart Block | Heart Failure | Myocardial Infarction | Hypertension | Stroke | Angina Pectoris
Known Adverse Events: Bradycardia | Hypotension | Dizziness | Pruritus | Depressive Disorder | Diarrhea
Company: AstraZeneca
Company Location: CAMBRIDGE X0 CB2 0AA
Company CEO: Pascal Soriot
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic: Australia, Norway, Spain, United States
Active Clinical Trial Count: 4
Highest Development Phases
Phase 3: Acute Lung Injury|Acute Respiratory Distress Syndrome|Cardiac Arrest|Cardiac Arrhythmias|Mitral Valve Prolapse|Respiratory Distress Syndrome, Newborn
Phase 2: Autism Spectrum Disorder
Phase 1: HIV Infections
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| FLECAPRO | P3 |
Recruiting |
Cardiac Arrhythmias|Mitral Valve Prolapse|Cardiac Arrest |
2026-02-01 |
|
| MAIDEN | P3 |
Not yet recruiting |
Acute Lung Injury|Acute Respiratory Distress Syndrome|Respiratory Distress Syndrome, Newborn |
2025-09-01 |
|
| 2006-7041-83/hah | P2 |
Not yet recruiting |
Autism Spectrum Disorder |
2021-07-16 |
|
| NCT04425902 | P1 |
Completed |
HIV Infections |
2021-03-10 |