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LB-100

Alternative Names: lb-100, lb100, lb 100
Latest Update: 2024-11-09
Latest Update Note: Clinical Trial Update

Product Description

Upon injection, PP2A inhibitor LB-100 inhibits the removal of phosphate groups from proteins essential for cell cycle progression. When used with radio- or chemotherapy treatment, this agent prevents the activation of PP2A-mediated repair mechanisms and allows for malignant cells to progress through the cell cycle without having their damaged DNA repaired.

Mechanisms of Action: WEE1 Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: LIXTE
Company Location: EAST SETAUKET NY 11733
Company CEO: John S. Kovach
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for LB-100

Countries in Clinic: United States

Active Clinical Trial Count: 2

Highest Development Phases

Phase 2: Fibrosarcoma|Leiomyosarcoma|Liposarcoma, Myxoid|Myelodysplastic Syndrome|Preleukemia|Synovial Sarcoma

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
ENHANCER

P2

Active, not recruiting

Leiomyosarcoma|Fibrosarcoma|Synovial Sarcoma|Liposarcoma, Myxoid

2024-12-20

MCC-19635

P2

Recruiting

Preleukemia|Myelodysplastic Syndrome

2021-05-01

23%

Recent News Events

Date

Type

Title

09/04/2024

News Article

 LIXTE Receives U.S. Patent Issue Notification for Immune Oncology

08/26/2024

News Article

 First Patient Dosed with LIXTE's LB-100 in New Clinical Trial to Treat Colorectal Cancer, Collaborating with NKI, Supported by Major Pharma Company

08/20/2024

News Article

 Exact Sciences Announces First Patient Enrolled in its Multi-Cancer Early Detection (MCED) Falcon Registry Real-World Evidence Study

08/19/2024

News Article

 LIXTE Biotechnology Provides Update On Recent Activities and Developments

05/10/2024

PubMed

 Enhancing oncogenic signaling to kill cancer cells.

05/01/2024

PubMed

 The phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing.

03/11/2024

PubMed

 Triple-Negative Myelofibrosis: Disease Features, Response to Treatment and Outcomes.

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