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JCAR-014

Alternative Names: jcar-014, jcar014, jcar 014
Latest Update: 2024-01-23
Latest Update Note: PubMed Publication

Product Description

anti-CD19-chimeric antigen receptor (CAR) lentiviral vector-transduced autologous T cells (Sourced from: https://www.clinicaltrials.gov/ct2/show/NCT02706405)

Mechanisms of Action: CAR-T,CD19

Novel Mechanism: No

Modality: CAR-T

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Fred Hutchinson Cancer Research Center
Company Location:
Company CEO:
Additional Commercial Interests: None

Clinical Description

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 1: Diffuse Large B-Cell Lymphoma|Lymphoma, Non-Hodgkin

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
NCI-2015-02286

P1

Terminated

Lymphoma, Non-Hodgkin|Diffuse Large B-Cell Lymphoma

2021-05-28

Recent News Events

Date

Type

Title

01/23/2024

PubMed

 Timing of anti-PD-L1 antibody initiation affects efficacy/toxicity of CD19 CAR T-cell therapy for large B-cell lymphoma.

06/30/2022

PubMed

 Impact of CD19 CAR T-cell product type on outcomes in relapsed or refractory aggressive B-NHL.

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