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Izokibep

Alternative Names: izokibep, aby-035, aby035, aby 035, afo2, aby-035/afo2, IMG020, IMG-020
Latest Update: 2024-09-30
Latest Update Note: Clinical Trial Update

Product Description

Izokibep is a unique antibody mimetic and potent interleukin-17A (IL-17A) inhibitor designed to overcome the limitations of existing monoclonal antibodies.

Mechanisms of Action: IL17A Inhibitor

Novel Mechanism: No

Modality: Antibody

Route of Administration: Subcutaneous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: ACELYRIN
Company Location:
Company CEO:
Additonal Commercial Interests: Affibody

Clinical Description

Map of Global Clinical Trials for Izokibep

Countries in Clinic: Austria, Bulgaria, Canada, China, Czech Republic, France, Germany, Hungary, Italy, Japan, Poland, Spain, United States, Unknown Location

Active Clinical Trial Count: 12

Highest Development Phases

Phase 3: Arthritis, Psoriatic|Hidradenitis Suppurativa

Phase 2: Panuveitis|Spondylitis, Ankylosing|Uveitis|Uveitis, Intermediate|Uveitis, Posterior

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
jRCT2031230501

P3

Not yet recruiting

Hidradenitis Suppurativa

2025-12-31

22107

P3

Unknown Status

Hidradenitis Suppurativa

2025-12-17

NCT05384249

P2

Active, not recruiting

Panuveitis

2025-08-07

21103

P2

Unknown Status

Uveitis, Posterior|Uveitis, Intermediate

2025-06-19

Recent News Events

Date

Type

Title

08/06/2024

News Article

 ACELYRIN, INC. to Report Second Quarter 2024 Financial Results and Corporate Update on August 13, 2024

06/05/2024

News Article

 ACELYRIN, INC. Announces Positive 16-week Data From its Global Phase 2b/3 Trial of Izokibep in Psoriatic Arthritis to be Shared During Late-Breaking Oral Presentation at EULAR 2024

05/29/2024

News Article

 ACELYRIN, INC. Announces Lonigutamab Phase 1/2 Proof-Of-Concept Data to be Shared During Late-Breaking Oral Presentation at ENDO 2024

04/29/2024

News Article

 ACELYRIN, INC. to Report First Quarter 2024 Financial Results and Corporate Update on May 13, 2024

03/19/2024

PubMed

 Efficacy and safety of pharmacological treatment of psoriatic arthritis: a systematic literature research informing the 2023 update of the EULAR recommendations for the management of psoriatic arthritis.

03/01/2024

PubMed

 An Update on Current Clinical Management and Emerging Treatments in Hidradenitis Suppurativa.

10/11/2023

PubMed

 IL-17 Inhibition: A Valid Therapeutic Strategy in the Management of Hidradenitis Suppurativa.

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