Product Description
Mechanisms of Action: RTK Inhibitor,C-Met Inhibitor,VEGFR Inhibitor
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: GSK
Company Location: BRENTFORD MIDDLESEX X0 TW8 9GS
Company CEO: Emma Walmsley
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Recent & Upcoming Milestones
Highest Development Phases
Phase 2: Squamous Cell Carcinoma|Head and Neck Cancer|Gastrointestinal Cancer|Non-Small-Cell Lung Cancer|Breast Cancer|Lung Cancer|Renal Cell Carcinoma
Phase 1: Hepatocellular Carcinoma|Oncology Solid Tumor Unspecified
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
Latest Trial Update Date |
Data Updated |
|---|---|---|---|---|---|---|---|
| NCT00920192 | P1 |
Completed |
Hepatocellular Carcinoma |
2012-03-07 |
2019-03-18 |
Treatments |
|
| MET111516 | P1 |
Completed |
Oncology Solid Tumor Unspecified |
2009-06-24 |
2019-03-18 |
Treatments |
|
| MET111648 | P1 |
Completed |
Oncology Solid Tumor Unspecified |
2009-05-02 |
2019-03-18 |
Treatments |
|
| MET111647 | P1 |
Completed |
Oncology Solid Tumor Unspecified |
2008-05-13 |
2019-03-18 |
Treatments |
|
| IND197 | P2 |
Completed |
Breast Cancer |
2014-12-14 |
2023-08-05 |
Primary Endpoints|Start Date|Treatments |
|
| I198 | P2 |
Completed |
Breast Cancer |
2014-05-14 |
2023-08-05 |
Primary Endpoints|Start Date|Treatments |
|
| NCT02034097 | P2 |
Withdrawn |
Non-Small-Cell Lung Cancer |
2014-04-01 |
2019-03-20 |
Treatments |
|
| I196 | P2 |
Completed |
Lung Cancer |
2014-03-21 |
2023-08-05 |
Primary Endpoints|Start Date |
|
| MET111644 | P2 |
Completed |
Renal Cell Carcinoma |
2010-08-18 |
2019-03-18 |
Treatments |
|
| MET111643 | P2 |
Completed |
Gastrointestinal Cancer |
2009-11-01 |
2019-03-18 |
Treatments |
|
| MET111646 | P2 |
Completed |
Squamous Cell Carcinoma|Head and Neck Cancer |
2009-05-02 |
2019-03-18 |
Treatments |