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Flutamide

Alternative Names: flutamide, eulexin
Latest Update: 2024-11-22
Latest Update Note: Clinical Trial Update

Product Description

Flutamide is a nonsteroidal antiandrogen that competitively binds androgen receptors throughout the body. This binding inhibits cell growth in prostate cancer by inhibiting testosterone’s stimulatory effects. The drug has a half-life of 6 hours, meaning dosing will have to occur a minimum of 3 times a day to maintain adequate serum levels. Flutamide is used in the management and treatment of androgen-dependent tumors like prostate cancer and conditions associated with hyperandrogenism like polycystic ovarian syndrome (PCOS). It is a prototypical drug of the anti-androgen class of medications. (Sourced from: https://www.ncbi.nlm.nih.gov/books/NBK482215/)

Mechanisms of Action: GnRH Agonist

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Approved

Approved Countries: Algeria | Argentina | Australia | Bangladesh | Belgium | Brazil | Bulgaria | Canada | Chile | Colombia | Croatia | Cyprus | Denmark | Dominican Republic | Ecuador | Egypt | Finland | France | Germany | Greece | Hong Kong | India | Ireland | Italy | Jordan | Latvia | Luxembourg | Malaysia | Malta | Mexico | Morocco | New Zealand | Norway | Pakistan | Peru | Philippines | Poland | Portugal | Romania | Russia | Serbia | Slovenia | South Africa | Spain | Sweden | Taiwan | Thailand | Turkey | Ukraine | United Kingdom | United States | Uruguay | Venezuela

Approved Indications: None

Known Adverse Events: None

Company: Radiation Therapy Oncology Group
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Flutamide

Countries in Clinic: United States

Active Clinical Trial Count: 2

Highest Development Phases

Phase 3: Adenocarcinoma|Bone Cancer|Prostate Cancer

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

PREDICT-RT*

P3

Recruiting

Prostate Cancer|Bone Cancer|Adenocarcinoma

2033-12-31

GUIDANCE

P3

Recruiting

Adenocarcinoma|Prostate Cancer

2032-04-30

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