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Encenicline

Alternative Names: encenicline, evp-6124, mt-4666
Latest Update: 2024-05-06
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: nAChR Agonist

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: FORUM
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Encenicline

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Alzheimer Disease|Schizophrenia|Cognitive Dysfunction

Phase 2: Alzheimer Disease|Smoking Cessation|Tobacco Use Disorder|Schizophrenia

Phase 1: Affective Disorders, Psychotic|Psychotic Disorders|Other|Schizophrenia|Healthy Volunteers|Kidney Diseases|Alzheimer Disease

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
EVP-6124-026

P3

Terminated

Alzheimer Disease

2017-08-01

EVP-6124-025

P3

Terminated

Alzheimer Disease

2017-01-01

EVP-6124-024

P3

Terminated

Alzheimer Disease

2017-01-01

EVP-6124-027

P2

Withdrawn

Alzheimer Disease

2016-10-01

Recent News Events

Date

Type

Title

05/06/2024

PubMed

 Advancements in Non-Dopaminergic Treatments for Schizophrenia: A Systematic Review of Pipeline Developments.

03/27/2024

PubMed

 Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig.

02/20/2024

PubMed

 Molecular Docking Analysis at the Human α7-nAChR and Proliferative and Evoked-Calcium Changes in SH-SY5Y Cells by Imidacloprid and Acetamiprid Insecticides.

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