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Dichloroacetate

Alternative Names: dichloroacetate, dca
Latest Update: 2024-10-24
Latest Update Note: Clinical Trial Update

Product Description

Mechanisms of Action: PDK Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: Colombia | India | Peru | Taiwan | United Kingdom

Approved Indications: None

Known Adverse Events: None

Company: University of Florida
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Dichloroacetate

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 4: Insulin Resistance

Phase 3: Acidosis, Lactic|Pyruvate Dehydrogenase Complex Deficiency Disease

Phase 2: Head and Neck Cancer|Healthy Volunteers|Non-Small-Cell Lung Cancer|Breast Cancer|Glioblastoma|MELAS Syndrome|Squamous Cell Carcinoma|Acidosis, Lactic|Glioma|Multiple Myeloma

Phase 1: Glioblastoma|MELAS Syndrome|Brain Cancer|Protein Deficiency|Liver Cancer|Potassium Deficiency|Acidosis, Lactic|Evans Syndrome|Lung Cancer|Breast Cancer|Tumor Lysis Syndrome|Healthy Volunteers|Brain Death|Brain Injuries|Hypertension, Pulmonary|Hyperglycemia|Familial Primary Pulmonary Hypertension|Hypoglycemia|Type 1 Diabetes|Pyruvate Dehydrogenase Complex Deficiency Disease|Deficiency Diseases|Head and Neck Cancer|Mitochondrial Diseases

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

HSC-MS-24-0756

N/A

Not yet recruiting

Generalized anxiety disorder

2027-06-30

DCA

P2

Not yet recruiting

Glioblastoma

2026-12-30

ACTRN12623001164684

N/A

Recruiting

Nose Cancer

2026-10-30

NCT05317455

P1

Not yet recruiting

Type 1 Diabetes|Hypoglycemia

2025-10-01

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