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Clozapine

Alternative Names: clozapine, clozaril, fazaclo, fazaclo odt, versacloz
Latest Update: 2024-06-05
Latest Update Note: News Article

Product Description

Clozapine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions) in people who have not been helped by other medications or who have tried to kill themselves and are likely to try to kill or harm themselves again. Clozapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain. (Sourced from: https://medlineplus.gov/druginfo/meds/a691001.html)

Mechanisms of Action: 5-HT2A Antagonist,5-HT2C Antagonist

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Approved

Approved Countries: Algeria | Argentina | Australia | Austria | Bangladesh | Belgium | Bosnia | Brazil | Bulgaria | Canada | Chile | China | Colombia | Croatia | Cyprus | Czech | Denmark | Dominican Republic | Ecuador | Egypt | Estonia | Finland | France | Germany | Greece | Hong Kong | Hungary | Iceland | India | Indonesia | Ireland | Israel | Italy | Japan | Jordan | Korea | Latvia | Lebanon | Lithuania | Luxembourg | Malaysia | Malta | Mexico | Morocco | Netherlands | New Zealand | Norway | Pakistan | Peru | Philippines | Poland | Portugal | Romania | Russia | Saudi Arabia | Serbia | Singapore | Slovakia | Slovenia | South Africa | Spain | Sri Lanka | Sweden | Switzerland | Taiwan | Thailand | Tunisia | Turkey | Ukraine | United Arab Emirates | United Kingdom | United States | Uruguay | Venezuela | Vietnam

Approved Indications: Suicidality | Schizophrenia | Suicidality | Schizophrenia

Known Adverse Events: Tachycardia | Hypotension | Dizziness | Headache | Tremor | Vertigo | Constipation

Company: Novartis
Company Location: BASEL V8 CH 4056
Company CEO: Vasant Narasimhan
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Clozapine

Countries in Clinic: China, Korea

Active Clinical Trial Count: 2

Highest Development Phases

Phase 1: Depressive Disorder|Hallucinations|Psychotic Disorders|Schizophrenia

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

WID-CLZ18-BE

P1

Completed

Schizophrenia

2022-08-14

43%

WID-CLZ18-BE

P1

Completed

Schizophrenia

2022-08-14

43%

CTR20130520

P1

Recruiting

Hallucinations|Psychotic Disorders|Depressive Disorder|Schizophrenia

None

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