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Becatecarin

Alternative Names: becatecarin
Latest Update: 2014-05-23
Latest Update Note: Clinical Trial Update

Product Description

Becatecarin (rebeccamaycin analogue-RA) is an anti-tumor antibiotic with inhibitory activity against both topoisomerase II and I as well as DNA intercalating properties. (Sourced from: https://ascopubs.org/doi/10.1200/jco.2008.26.15_suppl.19060)

Mechanisms of Action: TOP2 Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Helsinn Healthcare
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Becatecarin

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Biliary Tract Cancer

Phase 2: Liver Cancer|Gallbladder Cancer|Bile Duct Cancer|Male Breast Cancer|Primary Central Nervous System Lymphoma|Retinoblastoma|Brain Stem Cancer|Neuroblastoma|Sarcoma|Kidney Cancer|Small Cell Lung Cancer|Cholangiocarcinoma|Non-Small-Cell Lung Cancer|Renal Cell Carcinoma|Ovarian Cancer|Colorectal Cancer

Phase 1: Anemia, Aplastic|Acute Monocytic Leukemia|Chronic Myelomonocytic Leukemia|Acute Myeloid Leukemia|Anemia, Refractory, with Excess of Blasts|Chronic Lymphoid Leukemia|Myelodysplastic Syndrome|Blast Crisis|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Juvenile Myelomonocytic Leukemia,|Acute Myelomonocytic Leukemia|Preleukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Chronic Myeloid Leukemia|Acute Lymphoid Leukemia

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
NCI-2012-02587

P2

Terminated

Small Cell Lung Cancer

2008-04-01

NCI-2012-02609

P1

Completed

Precursor Cell Lymphoblastic Leukemia-Lymphoma|Chronic Myelomonocytic Leukemia|Acute Lymphoid Leukemia|Anemia, Refractory, with Excess of Blasts|Acute Myelomonocytic Leukemia|Acute Myeloid Leukemia|Blast Crisis|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Juvenile Myelomonocytic Leukemia,|Anemia, Aplastic|Preleukemia|Myelodysplastic Syndrome|Acute Monocytic Leukemia|Chronic Lymphoid Leukemia|Chronic Myeloid Leukemia

2007-01-01

XL119-001

P3

Terminated

Biliary Tract Cancer

2006-11-01

CDR0000066852

P2

Completed

Neuroblastoma

2006-09-01

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