Product Description
Becatecarin (rebeccamaycin analogue-RA) is an anti-tumor antibiotic with inhibitory activity against both topoisomerase II and I as well as DNA intercalating properties. (Sourced from: https://ascopubs.org/doi/10.1200/jco.2008.26.15_suppl.19060)
Mechanisms of Action: TOP2 Inhibitor
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Intravenous
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Helsinn Healthcare
Company Location:
Company CEO:
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Highest Development Phases
Phase 3: Biliary Tract Cancer
Phase 2: Liver Cancer|Gallbladder Cancer|Bile Duct Cancer|Male Breast Cancer|Primary Central Nervous System Lymphoma|Retinoblastoma|Brain Stem Cancer|Neuroblastoma|Sarcoma|Kidney Cancer|Small Cell Lung Cancer|Cholangiocarcinoma|Non-Small-Cell Lung Cancer|Renal Cell Carcinoma|Ovarian Cancer|Colorectal Cancer
Phase 1: Anemia, Aplastic|Acute Monocytic Leukemia|Chronic Myelomonocytic Leukemia|Acute Myeloid Leukemia|Anemia, Refractory, with Excess of Blasts|Chronic Lymphoid Leukemia|Myelodysplastic Syndrome|Blast Crisis|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Juvenile Myelomonocytic Leukemia,|Acute Myelomonocytic Leukemia|Preleukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Chronic Myeloid Leukemia|Acute Lymphoid Leukemia
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
---|---|---|---|---|---|
NCI-2012-02587 | P2 |
Terminated |
Small Cell Lung Cancer |
2008-04-01 |
|
NCI-2012-02609 | P1 |
Completed |
Precursor Cell Lymphoblastic Leukemia-Lymphoma|Chronic Myelomonocytic Leukemia|Acute Lymphoid Leukemia|Anemia, Refractory, with Excess of Blasts|Acute Myelomonocytic Leukemia|Acute Myeloid Leukemia|Blast Crisis|Myelogenous, Chronic, BCR-ABL Positive Leukemia|Juvenile Myelomonocytic Leukemia,|Anemia, Aplastic|Preleukemia|Myelodysplastic Syndrome|Acute Monocytic Leukemia|Chronic Lymphoid Leukemia|Chronic Myeloid Leukemia |
2007-01-01 |
|
XL119-001 | P3 |
Terminated |
Biliary Tract Cancer |
2006-11-01 |
|
CDR0000066852 | P2 |
Completed |
Neuroblastoma |
2006-09-01 |