Drug Search Results

Avosentan

Alternative Names: avosentan, spp-301, spp301, spp 301
Latest Update: 2023-02-08
Latest Update Note: PubMed Publication

Product Description

a predominant ETAreceptor antagonist (Sourced from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831858/)

Mechanisms of Action: ETa Antagonist

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: N/A

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Speedel Pharma
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Avosentan

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Diabetic Nephropathy|Kidney Failure, Chronic

Phase 2: Kidney Diseases

Trial	Phase	Trial Status	Disease	Primary Completion Date
2008-000786-32	P2	Completed	Kidney Diseases	2009-09-11
ASCEND	P3	Terminated	Diabetic Nephropathy	2006-12-18
SPP301CRD15	P3	Terminated	Diabetic Nephropathy\|Kidney Failure, Chronic	None

Recent News Events

Date	Type	Title
02/08/2023	PubMed	Endothelin Receptor Antagonists in Kidney Disease.
11/07/2021	PubMed	Endothelin Receptor Antagonists as a Potential Treatment of Diabetic Nephropathy: A Systematic Review.
01/01/2021	PubMed	Efficacy and safety of endothelin receptor antagonists in type 2 diabetic kidney disease: A systematic review and meta-analysis of randomized controlled trials.

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