Product Description
AR-42 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (Sourced from: https://clinicaltrials.gov/ct2/show/NCT01129193)
Mechanisms of Action: HDAC6 Inhibitor
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Alison Walker
Company Location:
Company CEO:
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Highest Development Phases
Phase 1: Renal Cell Carcinoma|Sarcoma|Neurofibromatoses|Neurofibromatosis 2|Meningioma|Neuroma, Acoustic|Acute Myeloid Leukemia|Kidney Diseases|Neurilemmoma|Burkitt Lymphoma|Lymphocytic Chronic B-Cell Leukemia|Chronic Lymphoid Leukemia|Precursor T-Cell Lymphoblastic Leukemia-Lymphoma|Extranodal NK-T-Cell Lymphoma|Mantle-Cell Lymphoma|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|Large-Cell Immunoblastic Lymphoma|Diffuse Large B-Cell Lymphoma|Multiple Myeloma|T-Cell Cutaneous Lymphoma|Intraocular Lymphoma|Mycosis Fungoides|Plasmablastic Lymphoma|Lymphoproliferative Disorders|Prolymphocytic Leukemia|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Lymphoma, Non-Hodgkin|Testicular Cancer|B-Cell Marginal Zone Lymphoma|Prolymphocytic T-Cell Leukemia|Follicular Lymphoma|Prolymphocytic B-Cell Leukemia|Waldenstrom Macroglobulinemia|Lymphomatoid Granulomatosis|Immunoblastic Lymphadenopathy|Large-Cell Anaplastic Lymphoma|T-Cell Peripheral Lymphoma|Leukemia, Plasma Cell|Sezary Syndrome|Adult T-Cell Leukemia-Lymphoma
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| OSU-15004 | P1 |
Completed |
Multiple Myeloma |
2020-11-14 |
|
| 14-078H | P1 |
Terminated |
Neurofibromatoses|Neuroma, Acoustic|Meningioma|Neurilemmoma|Neurofibromatosis 2 |
2017-05-30 |
|
| OSU-09102 | P1 |
Completed |
T-Cell Cutaneous Lymphoma|Burkitt Lymphoma|Follicular Lymphoma|Large-Cell Immunoblastic Lymphoma|Diffuse Large B-Cell Lymphoma|Adult T-Cell Leukemia-Lymphoma|Mantle-Cell Lymphoma|Precursor B-Cell Lymphoblastic Leukemia-Lymphoma|Prolymphocytic T-Cell Leukemia|Lymphocytic Chronic B-Cell Leukemia|Chronic Lymphoid Leukemia|Precursor T-Cell Lymphoblastic Leukemia-Lymphoma|Precursor Cell Lymphoblastic Leukemia-Lymphoma|Extranodal NK-T-Cell Lymphoma|T-Cell Peripheral Lymphoma|Multiple Myeloma|Immunoblastic Lymphadenopathy|Large-Cell Anaplastic Lymphoma|Lymphoma, Non-Hodgkin|Leukemia, Plasma Cell|Waldenstrom Macroglobulinemia|Prolymphocytic B-Cell Leukemia|Lymphomatoid Granulomatosis|Prolymphocytic Leukemia|Sezary Syndrome|Intraocular Lymphoma|Plasmablastic Lymphoma|Lymphoproliferative Disorders|Mycosis Fungoides|Testicular Cancer|B-Cell Marginal Zone Lymphoma |
2017-01-07 |
|
| MCC-14-10774 | P1 |
Terminated |
Kidney Diseases|Sarcoma|Renal Cell Carcinoma |
2016-11-24 |