Product Description
Aprepitant is used with other medications in adults and children 6 months of age and older to prevent nausea and vomiting that may occur after receiving cancer chemotherapy treatment. It is also used with other medications in adults and children 6 months of age and older to prevent delayed nausea and vomiting that may occur several days after receiving certain chemotherapy medications. Aprepitant is not used to treat nausea and vomiting that you already have. Aprepitant is in a class of medications called antiemetics. It works by blocking the action of neurokinin, a natural substance in the brain that causes nausea and vomiting. (Sourced from: https://medlineplus.gov/druginfo/meds/a604003.html)
Mechanisms of Action: NK1 Antagonist
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: None *
Approval Status: Approved
Approved Countries: Argentina | Australia | Austria | Bangladesh | Belgium | Brazil | Bulgaria | Canada | Chile | China | Colombia | Croatia | Cyprus | Czech | Denmark | Dominican Republic | Ecuador | Egypt | Estonia | European Medicines Agency | Finland | France | Germany | Greece | Hong Kong | Hungary | Iceland | India | Ireland | Israel | Italy | Japan | Jordan | Korea | Latvia | Lebanon | Lithuania | Luxembourg | Malaysia | Malta | Mexico | Netherlands | New Zealand | Norway | Pakistan | Peru | Philippines | Poland | Portugal | Romania | Russia | Saudi Arabia | Serbia | Singapore | Slovakia | Slovenia | South Africa | Spain | Sweden | Switzerland | Taiwan | Thailand | Tunisia | Turkey | Ukraine | United Arab Emirates | United Kingdom | United States | Uruguay | Venezuela | Vietnam
Approved Indications: Oncology Unspecified | Oncology Unspecified
Known Adverse Events: Hypotension | Abdominal Pain | Dizziness | Headache | Pain Unspecified | Neutropenia | Dehydration | Asthenia | Constipation | Diarrhea | Dyspepsia | Hiccup | Eructation
Company: Merck
Company Location: KENILWORTH NJ 07033
Company CEO: Robert M. Davis
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic: Belgium, China, France, Italy, Pakistan, Poland, Spain, United States
Active Clinical Trial Count: 6
Highest Development Phases
Phase 3: Acute Pain|Chronic Pain|Conduct Disorder|Depressive Disorder|Malnutrition|Morphine Dependence|Neuropathic Pain|Other|Pain, Postoperative
Phase 2: Fallopian Tube Cancer|Ovarian Cancer|Peritoneal Cancer
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| ZNâc3-005 | P2 |
Recruiting |
Peritoneal Cancer|Ovarian Cancer|Fallopian Tube Cancer |
2027-09-01 |
|
| STUDY19030022 | P3 |
Recruiting |
Morphine Dependence|Acute Pain|Pain, Postoperative |
2024-12-30 |
|
| DAVINCY | P3 |
Active, not recruiting |
Other |
2024-05-18 |
|
| LMRC-Aprepitant-Pain-01 | P3 |
Completed |
Depressive Disorder|Conduct Disorder|Chronic Pain|Malnutrition|Neuropathic Pain |
2023-10-31 |