Product Description
Apabetalone has been investigated for the treatment of Diabetes, Atherosclerosis, and Coronary Artery Disease. (Sourced from: https://pubchem.ncbi.nlm.nih.gov/compound/Apabetalone)
Mechanisms of Action: BET Inhibitor
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: Breakthrough Therapy - Type 2 Diabetes *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Resverlogix Corp
Company Location:
Company CEO:
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic: Canada
Active Clinical Trial Count: 3
Highest Development Phases
Phase 2: Familial Primary Pulmonary Hypertension|Hypertension, Pulmonary|Kidney Failure, Chronic
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| RVX222-CS-018 | P2 |
Not yet recruiting |
Kidney Failure, Chronic |
2026-11-22 |
24% |
| APPROACH-2 | P2 |
Not yet recruiting |
Hypertension, Pulmonary|Familial Primary Pulmonary Hypertension |
2025-03-01 |
|
| APPRoAcH-p | P1 |
Completed |
Familial Primary Pulmonary Hypertension|Hypertension, Pulmonary |
2021-10-15 |