Ozmosi | Anacetrapib Drug Profile

Product Description

Anacetrapib is a potent inhibitor of CETP that increases circulating levels of high-density lipoprotein (HDL) cholesterol and lowers the levels of non-HDL cholesterol [particularly low-density lipoprotein (LDL) cholesterol]. (Sourced from: https://doi.org/10.1093/eurheartj/ehab863)

Mechanisms of Action: CETP Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Merck
Company Location: Eastern America
Company Founding Year: 1668
Additional Commercial Interests: None

Clinical Description

Countries in Clinic:

Active Clinical Trial Count:

Recent & Upcoming Milestones

Highest Development Phases

Phase 2: Hypercholesterolemia|Hyperlipoproteinemia Type V|Hyperlipidemia|Dyslipidemia

Trial ID	Trial	Phase	Trial Status	Disease	Primary Completion Date	Probability of Success	Latest Trial Update Date	Data Updated
2011-004525-27	Study of Anaceptrapib in Heterozygous Familial Hypercholesterolemia	P3	Completed	Hypercholesterolemia	2018-11-13	35%	2022-03-13	Treatments
NCT02931188	REVEAL-Vasc	N/A	Completed	Atherosclerosis	2018-05-01		2019-03-21	Treatments
NCT01252953	REVEAL	P3	Active, not recruiting	Atherosclerosis	2017-01-31	35%	2022-05-04	Primary Endpoints
2010-023467-18	REVEAL Version 1.0	P3	Unknown status	Coronary Disease\|Myocardial Infarction	2016-09-25	35%	2025-07-04	Treatments
CTR20130983	CTR20130983	N/A	Completed	Hypercholesterolemia	2016-08-24		2025-04-29	Patient Enrollment\|Treatments
CTR20130982	CTR20130982	P3	Completed	Hypercholesterolemia	2015-08-20		2025-04-29	Patient Enrollment
NCT01860729	MK-0859-022	P3	Completed	Hypercholesterolemia	2015-05-29		2022-05-04	Primary Endpoints\|Treatments
NCT01760460	MK-0859-051 AM1	P3	Completed	Dyslipidemia	2015-03-04		2022-05-04	Primary Endpoints\|Treatments
JapicCTI-132236	JapicCTI-132236	P3	Completed	Dyslipidemia	2015-03-01
NCT01717300	MK-0859-021	P3	Completed	Hypercholesterolemia	2014-10-29		2022-05-04	Primary Endpoints\|Treatments
2012-003110-14	2012-003110-14	P3	Completed	Hypercholesterolemia	2014-10-29		2022-03-13	Treatments
NCT01841684	MK-0859-042	P3	Terminated	Hyperlipoproteinemias\|Hypercholesterolemia\|Hyperlipidemia\|Hyperlipoproteinemia Type II	2014-06-01		2022-05-04	Primary Endpoints
NCT01824238	MK-0859-050	P3	Completed	Hypercholesterolemia\|Hyperlipoproteinemia Type II	2014-05-01		2022-05-04	Primary Endpoints\|Treatments
JapicCTI-132234	JapicCTI-132234	P3	Completed	Hypercholesterolemia	2014-05-01
NCT01524289	REALIZE	P3	Completed	Hyperlipidemia\|Hypercholesterolemia\|Hyperlipoproteinemias\|Hyperlipoproteinemia Type II	2014-02-12	35%	2022-05-04
2012-002434-37	Anacetrapib in Patients with Homozygous Familial Hypercholesterolemia	P3	Terminated	Hypercholesterolemia	2014-02-04		2022-03-13	Treatments
2007-005839-28	Efficacy of Anacetrapib withStatin	P3	Completed	Coronary Disease	2012-12-03		2022-03-12	Treatments
NCT00990808	0859-026 AM3	P1	Completed	Dyslipidemia	2011-06-01		2022-05-04	Primary Endpoints\|Treatments
NCT01122667	MK-0859-038	P1	Completed	Dyslipidemia\|Kidney Diseases	2011-06-01		2022-05-04	Primary Endpoints\|Treatments
NCT01114490	MK-0859-039	P1	Completed	Liver Failure\|Dyslipidemia\|Hepatic Insufficiency	2010-07-01		2022-05-04	Primary Endpoints
NCT00977288	NCT00977288	P2	Completed	Dyslipidemia	2010-03-01		2022-05-04	Primary Endpoints\|Treatments
NCT00685776	DEFINE	P3	Completed	Myocardial Ischemia\|Coronary Artery Disease	2009-07-02		2022-05-04	Primary Endpoints
NCT00325455	NCT00325455	P2	Terminated	Hyperlipidemia\|Hyperlipoproteinemia Type V\|Hypercholesterolemia	2007-02-01		2022-05-04	Primary Endpoints\|Treatments
NCT00565006	NCT00565006	P1	Completed	Other	2006-09-01		2025-08-27	Treatments
NCT00565292	NCT00565292	P1	Completed	Hyperlipidemia\|Hypercholesterolemia\|Hyperlipoproteinemias	2006-08-01		2022-05-04	Treatments

Recent News Events

Date	Type	Title
04/22/2024	PubMed	CETP inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia-associated mortality in mice.
11/01/2023	PubMed	The evolving role of cholesteryl ester transfer protein inhibition beyond cardiovascular disease.
10/03/2023	PubMed	Impact of New Cardiovascular Events on Quality of Life and Hospital Costs in People With Cardiovascular Disease in the United Kingdom and United States.
08/11/2022	News Article	NewAmsterdam Pharma Announces Publication in Nature Medicine Discussing Clinical Potential of Obicetrapib
02/14/2022	News Article	New Review Article in ESC's Cardiovascular Research Examines Cholesteryl Ester Transfer Protein (CETP) Inhibition's Role in Reducing Cardiovascular Disease Risk
01/14/2021	News Article	NewAmsterdam Pharma Completes $196M (€160M) Series A Funding for Comprehensive Phase 3 Development Program
08/20/2019	News Article	Cardiovascular Drugs Market to be worth US$ 91.0 Billion by 2025, Says TMR

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Anacetrapib

Alternative Names: anacetrapib, mk0859, mk-0859, mk 0859 Clinical Status: Inactive Latest Update: 2024-04-22 Latest Update Note: PubMed Publication