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Gandotinib

Alternative Names: gandotinib, ly2784544
Latest Update: 2024-12-12
Latest Update Note: Clinical Trial Update

Product Description

Mechanisms of Action: JAK2 Inhibitor,STAT3 Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Eli Lilly
Company Location: INDIANAPOLIS IN 46285
Company CEO: David A. Ricks
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Gandotinib

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Thrombocythemia, Essential|Myelofibrosis|Polycythemia Vera|Myeloproliferative Disorders

Phase 1: Myeloproliferative Disorders|Polycythemia Vera|Thrombocythemia, Essential|Myelofibrosis|Thrombocytosis

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
I3X-MC-JHTB

P2

Unknown Status

Thrombocythemia, Essential|Polycythemia Vera|Myelofibrosis

2024-12-31

I3X-MC-JHTC

P1

Completed

Myeloproliferative Disorders|Thrombocytosis|Thrombocythemia, Essential|Myelofibrosis|Polycythemia Vera

2015-06-26

I3X-MC-JHTB

P2

Active, not recruiting

Myeloproliferative Disorders

2015-03-20

JHTB(a)

P2

Active, not recruiting

Myelofibrosis|Thrombocythemia, Essential|Polycythemia Vera

2015-02-09

Recent News Events

Date

Type

Title

09/15/2023

PubMed

 Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell proliferation through JAK2/STAT3 signaling pathway.

11/15/2022

PubMed

 Role of STAT3 in the initiation, progression, proliferation and metastasis of breast cancer and strategies to deliver JAK and STAT3 inhibitors.

05/12/2020

News Article

 Global Essential Thrombocythemia Market (2017 to 2030) - Insights, Epidemiology, and Market Forecast

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