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Ciliary neurotrophic factor

Alternative Names: ciliary neurotrophic factor, cntf
Latest Update: 2025-04-01
Latest Update Note: News Article

Product Description

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. (Sourced from: https://www.ncbi.nlm.nih.gov/gene/1270)

Mechanisms of Action: No Mechanism

Novel Mechanism: No

Modality: Peptide/Protein

Route of Administration: N/A

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Neurotech
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Retinitis Pigmentosa|Usher Syndromes|Telangiectasis|Color Vision Defects

Phase 1: Optic Nerve Diseases|Optic Neuropathy, Ischemic|Ischemic Stroke|Optic Neuritis|Glaucoma, Open-Angle|Retinitis Pigmentosa

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success

NTMT-01/02E

P2

Completed

Telangiectasis

2021-05-11

24%

AOSLO-CNTF-FFB-01

P2

Completed

Retinitis Pigmentosa|Usher Syndromes

2019-07-01

NTMT-02

P2

Completed

Telangiectasis

2017-04-14

22%

NCT01408472

P1

Completed

Glaucoma, Open-Angle

2013-12-01

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