Product Description
BMS 599626 is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM. BMS-599626 is identified as an ATP-competitive inhibitor for HER1 and as an ATP-noncompetitive inhibitor for HER2. BMS-599626 inhibits the proliferation of tumor cells expressing high levels of HER1 and/or HER2, including Sal2, BT474, N87, KPL-4, HCC202, HCC1954, HCC1419, AU565, ZR-75-30, MDA-MB-175, GEO, and PC9 cells. (Sourced from: https://drugs.ncats.io/drug/2252724U5N)
Mechanisms of Action: EGFR Inhibitor, HER2 Inhibitor, HER4 Inhibitor, TK Inhibitor
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Bristol-Myers Squibb
Company Location: Eastern America
Company Founding Year: 1989
Additional Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Recent & Upcoming Milestones
Highest Development Phases
Phase 1: Oncology Solid Tumor Unspecified|Glioma
Trial ID |
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
Latest Trial Update Date |
Data Updated |
|---|---|---|---|---|---|---|---|---|
NCT00979173 |
Pro00018751 | P1 |
Completed |
Glioma |
2010-10-01 |
2019-03-19 |
Treatments |
|
NCT00095537 |
CA181-002 | P1 |
Completed |
Oncology Solid Tumor Unspecified |
2006-05-01 |
2019-03-21 |
Treatments |
|
NCT00207012 |
MAD Refractory | P1 |
Completed |
Oncology Solid Tumor Unspecified |
2006-02-01 |
2019-03-21 |
Treatments |
Recent News Events
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