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AZD7986

Alternative Names: azd7986
Latest Update: 2024-01-22
Latest Update Note: Clinical Trial Update

Product Description

AZD7986 is a small‐molecule, competitive, and reversible inhibitor of DPP1, with high potency and selectivity as measured in vitro. (Sourced from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282495/)

Mechanisms of Action: DPP1 Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: AstraZeneca
Company Location: CAMBRIDGE X0 CB2 0AA
Company CEO: Pascal Soriot
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for AZD7986

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 1: Healthy Volunteers

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
D6190C00001

P1

Completed

Healthy Volunteers

2016-08-03

D6190C00003

P1

Completed

Healthy Volunteers

2016-04-13

Recent News Events

Date

Type

Title

12/14/2023

PubMed

 Dipeptidyl peptidase 1 inhibition as a potential therapeutic approach in neutrophil-mediated inflammatory disease.

11/09/2023

PubMed

 Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats.

09/25/2023

PubMed

 Periodontal Effects of the Reversible Dipeptidyl Peptidase 1 Inhibitor Brensocatib in Bronchiectasis.

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