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ADL5859

Alternative Names: adl5859, adl-5859, adl 5859
Latest Update: 2022-09-26
Latest Update Note: PubMed Publication

Product Description

novel delta opioid agonist that shows good oral bioavailability, analgesic and antidepressive effects in the rat, and represent potential drug to treat chronic pain. (Sourced from: https://jpet.aspetjournals.org/content/early/2012/06/13/jpet.111.188987)

Mechanisms of Action: OPRD Agonist

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: N/A

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Bristol-Myers Squibb
Company Location: NEW YORK NY 10016
Company CEO: Giovanni Caforio
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for ADL5859

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Arthritis, Rheumatoid|Neuralgia|Acute Pain|Osteoarthritis, Knee|Peripheral Nervous System Diseases|Neuropathic Pain

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
44CL240

P2

Completed

Osteoarthritis, Knee

2010-04-01

33CL232

P2

Completed

Arthritis, Rheumatoid

2008-09-01

33CL231

P2

Completed

Neuralgia|Peripheral Nervous System Diseases|Neuropathic Pain

2008-08-01

33CL230

P2

Completed

Acute Pain

2007-09-01

Recent News Events

Date

Type

Title

09/26/2022

PubMed

 Development of a novel cell-based, In-Cell Western/ERK assay system for the high-throughput screening of agonists acting on the delta-opioid receptor.

08/11/2022

PubMed

 Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions.

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