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Tandutinib

Alternative Names: tandutinib, ct53518, mln-518, mln518
Latest Update: 2023-07-18
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: RTK Inhibitor,PGFR Inhibitor

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Takeda
Company Location: TOKYO M0 103-8668
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Tandutinib

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Acute Myeloid Leukemia|Prostate Cancer|Astrocytoma|Gliosarcoma|Oligodendroglioma|Glioblastoma|Renal Cell Carcinoma|Brain Cancer

Phase 1: Preleukemia|Acute Myeloid Leukemia|Glioblastoma|Myelodysplastic Syndrome

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
NCI-2009-00681

P2

Completed

Gliosarcoma|Glioblastoma|Brain Cancer

2012-09-01

08-C-0101

P2

Completed

Astrocytoma|Gliosarcoma|Oligodendroglioma|Glioblastoma

2011-07-01

C03003

P1

Withdrawn

Glioblastoma

2010-05-01

NCI-2012-02865

P2

Completed

Prostate Cancer

2009-11-01

Recent News Events

Date

Type

Title

07/18/2023

PubMed

 Identification of potential RapJ hits as sporulation pathway inducer candidates in Bacillus coagulans via structure-based virtual screening and molecular dynamics simulation studies.

08/01/2022

PubMed

 Esterase-responsive and size-optimized prodrug nanoparticles for effective intracranial drug delivery and glioblastoma treatment.

09/01/2021

PubMed

 CCT245718, a dual FLT3/Aurora A inhibitor overcomes D835Y-mediated resistance to FLT3 inhibitors in acute myeloid leukaemia cells.

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