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Enoximone

Alternative Names: enoximone
Latest Update: 2023-08-01
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: PDE3 Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: France | Ireland | Italy | Malta | Netherlands | United Kingdom

Approved Indications: None

Known Adverse Events: None

Company: Gilead Sciences
Company Location: FOSTER CITY CA 94404
Company CEO: Daniel P. O’Day
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Enoximone

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 4: Chronic Obstructive Pulmonary Disease|Healthy Volunteers

Phase 3: Heart Failure

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
2019-002826-58

P4

Active, not recruiting

Chronic Obstructive Pulmonary Disease

2022-01-15

NCT04420455

P4

Terminated

Chronic Obstructive Pulmonary Disease

2021-12-21

2006-004066-14

P4

Active, not recruiting

Healthy Volunteers

2007-08-22

EMPOWER (Protocol My-023)

P3

Terminated

Heart Failure

2005-06-01

Recent News Events

Date

Type

Title

08/01/2023

PubMed

 Retraction Note: Phosphodiesterase-inhibitors enoximone and piroximone in cardiac surgery: influence on platelet count and function.

07/01/2023

PubMed

 Retraction Note: The new phosphodiesterase inhibitor enoximone in patients following cardiac surgery - pharmacokinetics and influence on parameters of coagulation.

04/01/2023

PubMed

 Retraction Notice to: "Efficacy of the Phosphodiesterase Inhibitor Enoximone in Complicated Cardiac Surgery" [Chest. 1990;98(1):53-58].

03/18/2019

News Article

 Identification of Phosphodiesterease 3A Polymorphism With Potential to Increase Effectiveness of PDE3 Inhibitors Published in the Journal of the American College of Cardiology

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