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Rifalazil

Alternative Names: rifalazil
Latest Update: 2023-06-15
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: RNA polymerase Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: N/A

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: ActivBiotics
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Rifalazil

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Peripheral Arterial Disease|Intermittent Claudication|Peripheral Vascular Diseases

Phase 2: Peripheral Arterial Disease|Trachoma|Communicable Diseases|Chlamydia Infections|Myocardial Ischemia|Cerebrovascular Disorders|Coronary Artery Disease|Peripheral Vascular Diseases

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
APL-1648-027

P2

Completed

Communicable Diseases|Chlamydia Infections|Trachoma

2013-03-01

PROVIDENCE-1

P3

Unknown status

Peripheral Arterial Disease|Intermittent Claudication|Peripheral Vascular Diseases

None

ABI-1648-026

P2

Unknown status

Peripheral Arterial Disease|Myocardial Ischemia|Cerebrovascular Disorders|Coronary Artery Disease|Peripheral Vascular Diseases

None

Recent News Events

Date

Type

Title

06/15/2023

PubMed

 CRISPR Interference-Based Inhibition of MAB_0055c Expression Alters Drug Sensitivity in Mycobacterium abscessus.

10/06/2022

PubMed

 Therapeutic efficacy of rifalazil (KRM-1648) in a M. ulcerans-induced Buruli ulcer mouse model.

08/12/2022

PubMed

 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.

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