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Revusiran

Alternative Names: revusiran
Latest Update: 2021-01-01
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: TTR Inhibitor

Novel Mechanism: No

Modality: Nucleic Acid

Route of Administration: Subcutaneous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Alnylam
Company Location: CAMBRIDGE MA 02142
Company CEO: Yvonne L. Greenstreet
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Revusiran

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Transthyretin Amyloidosis|Cardiomyopathies|Amyloidosis, Familial|Amyloid Neuropathies, Familial

Phase 2: Amyloidosis|Transthyretin Amyloidosis|Polyneuropathies|Amyloidosis, Familial|Amyloid Neuropathies, Familial

Phase 1: Amyloidosis

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
ENDEAVOUR

P3

Completed

Amyloidosis, Familial|Cardiomyopathies|Amyloid Neuropathies, Familial|Transthyretin Amyloidosis

2017-03-30

2014-003835-20

P3

Completed

Transthyretin Amyloidosis

2017-03-30

ALN-TTRSC-003

P2

Completed

Amyloidosis

2017-02-22

2014-001229-34

P2

Completed

Transthyretin Amyloidosis

2017-02-22

Recent News Events

Date

Type

Title

01/01/2021

PubMed

 Targeted Therapies for Hereditary Peripheral Neuropathies: Systematic Review and Steps Towards a 'treatabolome'.

12/01/2020

PubMed

 Correction to: Phase 3 Multicenter Study of Revusiran in Patients with Hereditary Transthyretin-Mediated (hATTR) Amyloidosis with Cardiomyopathy (ENDEAVOUR).

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