Product Description
Dobutamine is used as a pharmacological agent and has both ionotropic and chronotropic effects depending on the dose. Because of its inotropic effects on the myocardium through binding and activating the beta-1 receptors selectively.[7] The medication is indicated clinically for decompensated congestive heart failure because of the sympathomimetic effects. Dobutamine's ionotropic effect increases contractility, leading to decreased end-systolic volume and, therefore, increased stroke volume. (Sourced from: https://www.ncbi.nlm.nih.gov/books/NBK470431/)
Mechanisms of Action: ADRB1 Agonist
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Intravenous
FDA Designation: None *
Approval Status: Approved
Approved Countries: Algeria | Argentina | Australia | Austria | Bangladesh | Belgium | Bosnia | Brazil | Bulgaria | Canada | Chile | China | Colombia | Croatia | Czech | Denmark | Dominican Republic | Ecuador | Egypt | Finland | France | Germany | Greece | Hong Kong | Hungary | Iceland | India | Indonesia | Ireland | Italy | Japan | Jordan | Korea | Lebanon | Lithuania | Luxembourg | Malaysia | Malta | Mexico | Morocco | Netherlands | New Zealand | Norway | Pakistan | Peru | Philippines | Poland | Portugal | Romania | Russia | Saudi Arabia | Serbia | Singapore | Slovakia | Slovenia | South Africa | Spain | Sri Lanka | Sweden | Switzerland | Taiwan | Thailand | Tunisia | Turkey | Ukraine | United Arab Emirates | United Kingdom | United States | Uruguay | Venezuela | Vietnam
Approved Indications: None
Known Adverse Events: None
Company: AZIENDA UNITA`NITARIA LOCALE N 12 DI VIAREGGIO
Company Location:
Company CEO:
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic: Denmark
Active Clinical Trial Count: 3
Highest Development Phases
Phase 2: Myocardial Infarction|Shock, Cardiogenic|Transthyretin Amyloidosis
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
---|---|---|---|---|---|
2023-508298-10-00 | P2 |
Unknown Status |
Transthyretin Amyloidosis |
2025-12-01 |
|
DOBERMANN | P2 |
Recruiting |
Myocardial Infarction|Shock, Cardiogenic |
2025-03-01 |
|
Neocirculation 003 | P3 |
Active, not recruiting |
Unknown |
2022-11-29 |