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Mapatumumab

Alternative Names: mapatumumab
Latest Update: 2023-12-04
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: TNFS10A Antagonist

Novel Mechanism: Yes

Modality: Antibody

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: GlaxoSmithKline
Company Location: BRENTFORD MIDDLESEX X0 TW8 9GS
Company CEO: Emma Walmsley
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Mapatumumab

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Non-Small-Cell Lung Cancer|Multiple Myeloma|Hepatocellular Carcinoma|Cervical Cancer|Uterine Cancer

Phase 1: Hepatocellular Carcinoma

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
2006-7041-83/hah

N/A

Not yet recruiting

Type 1 Diabetes|Depressive Disorder

2021-07-30

24-11-2009 (versions 2.0)

P2

Completed

Cervical Cancer|Uterine Cancer

2014-03-01

HGS1012-C1103

P2

Completed

Hepatocellular Carcinoma

2013-05-31

2010-020798-17

P2

Completed

Hepatocellular Carcinoma

2013-04-18

Recent News Events

Date

Type

Title

12/04/2023

PubMed

 Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway.

07/11/2023

PubMed

 TRAIL-mediated signaling in bladder cancer: realization of clinical efficacy of TRAIL-based therapeutics in medical oncology.

01/15/2022

PubMed

 miR-3132 upregulates surface TRAIL to induce apoptotic cell death in cancer cells.

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