Drug Search Results

Decernotinib

Alternative Names: decernotinib, vx-509
Latest Update: 2024-02-26
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: JAK1 Inhibitor,JAK2 Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Vertex
Company Location: BOSTON MA 02210
Company CEO: Reshma Kewalramani
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Decernotinib

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Arthritis, Rheumatoid

Phase 1: Healthy Volunteers

Trial	Phase	Trial Status	Disease	Primary Completion Date
2011-004419-22	P2	Completed	Arthritis, Rheumatoid	2014-07-31
2012-004342-14	P3	Terminated	Arthritis, Rheumatoid	2014-07-28
VX12-509-104	P3	Completed	Arthritis, Rheumatoid	2014-07-01
VX11-509-102	P2	Completed	Arthritis, Rheumatoid	2014-07-01

Recent News Events

Date	Type	Title
02/26/2024	PubMed	VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling.
10/05/2023	PubMed	Azaindole derivatives as potential kinase inhibitors and their SARs elucidation.
02/28/2023	PubMed	Okadaic Acid Activates JAK/STAT Signaling to Affect Xenobiotic Metabolism in HepaRG Cells.
04/24/2019	News Article	Aclaris Therapeutics Announces Issuance of a Patent Covering the use of Ruxolitinib and its Deuterated Forms to Treat Alopecia Areata

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