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Darapladib

Alternative Names: darapladib, sb 480848, sb-480848, sb480848
Latest Update: 2024-03-09
Latest Update Note: PubMed Publication

Product Description

Mechanisms of Action: PLA2 Inhibitor

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: Oral

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: GlaxoSmithKline
Company Location: BRENTFORD MIDDLESEX X0 TW8 9GS
Company CEO: Emma Walmsley
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Darapladib

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Coronary Disease|Atherosclerosis|Acute Coronary Syndrome|Coronary Artery Disease|Myocardial Ischemia

Phase 2: Myocardial Ischemia|Coronary Artery Disease|Atherosclerosis|Diabetic Retinopathy|Dyslipidemia|Macular Edema

Phase 1: Atherosclerosis|Blister|Type 2 Diabetes|Kidney Diseases|Asthma

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
5R01HL092954

P3

Completed

Atherosclerosis

2015-11-01

NCT02058641

P1

Completed

Atherosclerosis|Blister|Type 2 Diabetes

2014-08-18

JapicCTI-101024

P3

Completed

Acute Coronary Syndrome

2014-04-30

SB-480848/033

N/A

Completed

Coronary Artery Disease|Myocardial Ischemia

2014-04-01

Recent News Events

Date

Type

Title

03/09/2024

PubMed

 Combination of theoretical analysis and experiments: Exploring the role of PLA2G7 in human cancers, including renal cancer.

01/25/2024

PubMed

 Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma.

09/15/2023

PubMed

 The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism.

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