Product Description
Cholecalciferol (vitamin D3) is used as a dietary supplement when the amount of vitamin D in the diet is not enough. People most at risk for vitamin D deficiency are older adults, breastfed infants, people with dark skin, obese people, and those with limited sun exposure, or gastrointestinal disease (GI; affecting the stomach or intestines) such as Crohn's disease or celiac disease.
Mechanisms of Action: VDR Agonist
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: Algeria | Argentina | Australia | Austria | Bangladesh | Belgium | Bosnia | Brazil | Bulgaria | Canada | Chile | China | Colombia | Croatia | Cyprus | Czech | Denmark | Dominican Republic | Ecuador | Egypt | Estonia | European Medicines Agency | Finland | France | Germany | Greece | Hong Kong | Hungary | Iceland | India | Indonesia | Ireland | Israel | Italy | Japan | Jordan | Korea | Latvia | Lebanon | Lithuania | Luxembourg | Malaysia | Malta | Mexico | Morocco | Netherlands | New Zealand | Norway | Pakistan | Peru | Philippines | Poland | Portugal | Romania | Russia | Saudi Arabia | Serbia | Singapore | Slovakia | Slovenia | South Africa | Spain | Sri Lanka | Sweden | Switzerland | Taiwan | Thailand | Tunisia | Turkey | Ukraine | United Arab Emirates | United Kingdom | United States | Uruguay | Venezuela | Vietnam
Approved Indications: Vitamin D Deficiency
Known Adverse Events: Diplopia | Dizziness | Headache | Erythema | Anaphylaxis
Company: Merck
Company Location: KENILWORTH NJ 07033
Company CEO: Robert M. Davis
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic: Belgium, China, Czech Republic, Estonia, France, Germany, Hungary, Netherlands, Poland, Spain, Sweden, United States
Active Clinical Trial Count: 9
Highest Development Phases
Phase 3: COVID-19|Type 1 Diabetes
Phase 2: Communicable Diseases|Pancreatic Cancer|Type 2 Diabetes|Urinary Tract Infections
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| 2024-514834-19-00 | P2 |
Unknown Status |
Type 2 Diabetes |
2030-12-31 |
|
| DOVIPA | P2 |
Not yet recruiting |
Pancreatic Cancer |
2028-01-15 |
|
| DIAGNODE-3 | P3 |
Unknown Status |
Type 1 Diabetes |
2027-12-31 |
|
| DIAGNODE-3 | P3 |
Recruiting |
Type 1 Diabetes |
2027-12-01 |