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Cinaciguat

Alternative Names: cinaciguat, bay 58-2667, bay 58 2667, bay 582667
Latest Update: 2024-12-01
Latest Update Note: PubMed Publication

Product Description

Cinaciguat (BAY 58-2667) is a novel soluble guanylate cyclase activator. (Sourced from: https://pubmed.ncbi.nlm.nih.gov/22778174/)

Mechanisms of Action: sGC Activator

Novel Mechanism: Yes

Modality: Small Molecule

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Elanco Animal Health
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Cinaciguat

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 2: Heart Failure|Heart Failure, Acute|Heart Failure, Chronic

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
2009-014378-16

P2

Terminated

Heart Failure, Chronic|Heart Failure, Acute

2011-03-01

COMPOSE EARLY

P2

Terminated

Heart Failure

2011-02-01

2009-014377-40

P2

Terminated

Heart Failure, Chronic|Heart Failure, Acute

2011-01-09

JapicCTI-101079

P2

Terminated

Heart Failure

2011-01-01

Recent News Events

Date

Type

Title

12/01/2024

PubMed

 Role of the NO-GC/cGMP signaling pathway in platelet biomechanics.

08/01/2023

PubMed

 Novel application potential of cinaciguat in the treatment of mixed hyperlipidemia through targeting PTL/NPC1L1 and alleviating intestinal microbiota dysbiosis and metabolic disorders.

06/01/2023

PubMed

 Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia and associated LUTS.

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