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Cizolirtine

Alternative Names: cizolirtine
Latest Update: 2022-07-01
Latest Update Note: PubMed Publication

Product Description

Cizolirtine citrate is a promising agent in the treatment of OAB with urinary incontinence. Cizolirtine citrate caused fewer antimuscarinic but more gastrointestinal (nausea) and neurologic (headache and vertigo) adverse events than oxybutynin. (Sourced from: https://pubmed.ncbi.nlm.nih.gov/19446951/)

Mechanisms of Action: N/A

Novel Mechanism: No

Modality: Small Molecule

Route of Administration: N/A

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Laboratorios del Dr. Esteve
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Cizolirtine

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 3: Urinary Incontinence, Urge

Phase 2: Urinary Incontinence, Stress

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
2004-001119-69

P3

Active, not recruiting

Urinary Incontinence, Urge

2006-10-16

2005-000107-33

P2

Completed

Urinary Incontinence, Stress

2006-03-23

2004-001116-31

P3

Completed

Urinary Incontinence, Urge

2004-12-21

Recent News Events

Date

Type

Title

07/01/2022

PubMed

 Results from two-year rodent oral carcinogenicity studies of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator.

06/01/2021

PubMed

 Twenty six-week repeat dose oral rat toxicity study of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator.

02/01/2021

PubMed

 Assessment of the Genotoxic Potential of Cizolirtine a Substance-P and Calcitonin Gene-Related Peptide Release Modulator.

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