Product Description
AU5-5 is a highly selective FLT3 inhibitor, showing picomolar potencies against FLT3 and all eight possible mutations of FLT3, including FLT3 (ITD), FLT3 (D835Y), FLT3 (F594_R595insR), FLT3 (F594_R595insREY), FLT3 (ITD)-NPOS, FLT3 (ITD)-W51, FLT3 (R595_E596insEY) and FLT3 (Y591V592insVDFREYEYD), in a panel screen of 370 human kinases. AU5-5 is highly cytotoxic in FLT3-positive leukaemic cells and holds the advantage of addressing the resistance issue that has been commonly seen in current FLT3 inhibitor treatment. AU5-5 was highly efficacious against tumor xenografts and caused a complete remission in all animals bearing AML cancer cells, translating to a 100% survival rate. Moreover, AU5-5 is highly synergistic to venetoclax, a BCL-1 inhibitor, and has the potential to address venetoclax resistance. AU5-5 is in the late stage of preclinical CMC, DMPK/Tox studies. (Sourced from: https://www.aucentra.com/drug-development-pipeline/#AU2-85)
Mechanisms of Action: FLT3 Inhibitor
Novel Mechanism: No
Modality: Small Molecule
Route of Administration: N/A
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Aucentra
Company Location:
Company CEO:
Additonal Commercial Interests: None
Clinical Description
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Highest Development Phases
Phase 0: Leukemia
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