Product Description
AU2-85 is an oral, highly potent and selective CDK8 inhibitor that shows high efficacy against haematological malignancies through STAT1/5 pathway. CDK8 regulates transcription of cytokines via this pathway, thereby interfering with the immune responses. Natural killer (NK) cells serve as the first-line defense against transformed and infected cells. Therefore, AU2-85 has been an ideal candidate for promoting NK cells-mediated tumour immune surveillance, apart from increasing the efficacy of chemotherapies. The anticancer efficacy and safety profiles in animal models has been well demonstrated upon treatment with AU2-85. In addition to its single agent anti-tumour efficacy, AU2-85 has demonstrated marked activity when combining targeted therapy or chemotherapy and has the potential to address their resistance. Currently, AU2-85 is in late stage of preclinical studies. (Sourced from: https://www.aucentra.com/drug-development-pipeline/#AU2-85)
Mechanisms of Action: CDK8 Inhibitor
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Aucentra
Company Location:
Company CEO:
Additonal Commercial Interests: None
Clinical Description
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Highest Development Phases
Phase 0: Oncology Hematological Unspecified
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