Product Description
JCXH-108 is a monovalent RSV vaccine being developed by Immorna using its proprietary mRNA and RTU-LNP technologies. Both technologies have gained successful clinical proof-of-concept through clinical trials of other infectious disease vaccines at Immorna. JCXH-108 features a mild storage and transportation condition with shelf life of approximately 18 months at 2-8 °C, which greatly improve the mRNA vaccine's accessibility. JCXH-108 mRNA encodes an engineered RSV Fusion protein with stabilized pre-fusion configuration (pre-F). The antigen design went through extensive screening and optimization and is proprietary for Immorna. In preclinical studies, the pre-F antigen demonstrated high in vitro and in vivo expression from the mRNA. Very low doses of JCXH-108 elicited high titers of neutralizing antibodies against both RSV A and RSV B strains. Immunization of cotton rats with low dose of JCXh-1108 achieved complete protection against RSV virus challenge. (Sourced from: https://www.prnewswire.com/news-releases/immorna-receives-grant-from-bill--melinda-gates-foundation-to-support-its-mrna-rsv-vaccine-clinical-development-302229974.html)
Mechanisms of Action: Vaccine
Novel Mechanism: No
Modality: Vaccine
Route of Administration: Injection
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Immorna Biotherapeutics, Inc.
Company Location:
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Additonal Commercial Interests: None
Clinical Description
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