Product Description
RLA-23174 is a new small molecule allosteric inhibitor of HIPK2 and a potential first-in-class treatment for pan-organ fibrosis. RLA-23174 inhibits the TGF-beta/Smad3 signaling pathway by affecting the interaction between HIPK2 and Smad3, without inhibiting the kinase activity of HIPK2 or TGF-beta receptor systems. Therefore, RLA-23174 exerts anti-fibrotic effects by reducing TGF-beta signaling without serious adverse effects caused by complete HIPK2 or TGF-beta signaling blockade. Preclinical studies have shown that RLA-23174 has superior anti-fibrotic effects, significant in vivo activity, excellent pharmacokinetic properties in animals, and a good safety profile. RLA-23174 demonstrates good druggability and excellent development potential. (Sourced from: https://www.prnewswire.com/news-releases/rila-therapeutics-announces-dosing-of-first-cohort-in-phase-1-clinical-trial-of-rla-23174-a-first-in-class-hipk2-allosteric-inhibitor-for-treatment-of-chronic-kidney-disease-and-fibrosis-302150159.html)
Mechanisms of Action: HIPK2 Inhibitor
Novel Mechanism: Yes
Modality: Small Molecule
Route of Administration: Oral
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Shanghai YingLi Pharmaceutical
Company Location:
Company CEO:
Additonal Commercial Interests: None
Clinical Description
Countries in Clinic:
Active Clinical Trial Count:
Highest Development Phases
Phase 1: Healthy Volunteers
Trial |
Phase |
Trial Status |
Disease |
Primary Completion Date |
Probability of Success |
|---|---|---|---|---|---|
| CTR20241636 | P1 |
Unknown |
Healthy Volunteers |
None |