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Trastuzumab duocarmazine

Alternative Names: Trastuzumab duocarmazine, SYD-985, SYD985, trastuzumab vc-seco-DUBA
Latest Update: 2023-12-15
Latest Update Note: Clinical Trial Update

Product Description

Mechanisms of Action: ERBB2 Inhibitor

Novel Mechanism: No

Modality: Antibody Drug Conjugate

Route of Administration: Intravenous

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: Byondis
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for Trastuzumab duocarmazine

Countries in Clinic: Belgium, Canada, Denmark, France, Italy, Korea, Netherlands, Poland, Russia, Serbia, Singapore, Spain, Sweden, Ukraine, United Kingdom, United States

Active Clinical Trial Count: 7

Highest Development Phases

Phase 3: Breast Cancer

Phase 2: Adenocarcinoma|Endometrial Cancer|Esophageal Cancer|Gastrointestinal Cancer

Phase 1: Ovarian Cancer

Trial

Phase

Trial Status

Disease

Primary Completion Date

Probability of Success
2020-005575-12

P2

Active, not recruiting

Breast Cancer|Gastrointestinal Cancer|Adenocarcinoma|Esophageal Cancer

2023-06-30

SYD985.004

P1

Completed

Ovarian Cancer|Endometrial Cancer|Breast Cancer

2023-04-24

27%
BYON5667.002

P2

Completed

Breast Cancer

2023-04-19

57%
BYON5667.002

P2

Completed

Breast Cancer

2023-04-19

57%
SYD985.003

P2

Completed

Endometrial Cancer

2023-01-26

Recent News Events

Date

Type

Title

09/12/2023

PubMed

 Clinical Impact of New Treatment Strategies for HER2-Positive Metastatic Breast Cancer Patients with Resistance to Classical Anti-HER Therapies.

01/12/2023

PubMed

 The change of paradigm in the treatment of HER2-positive breast cancer with the development of new generation antibody-drug conjugates.

12/16/2022

PubMed

 Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody-Drug Conjugates in Breast Cancer.

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