Product Description
KRRO-110 is the first RNA editing oligonucleotide candidate from Korro’s proprietary OPERA™ platform. Korro has demonstrated the ability to repair the misfolding of the Alpha-1 Antitrypsin (A1AT) protein containing the Z mutation, as well as reduce liver aggregates, in a preclinical mouse model. (Sourced from: https://www.korrobio.com/press-releases/korro-announces-selection-of-its-first-development-candidate-for-the-potential-treatment-of-alpha-1-antitrypsin-deficiency-aatd/)
Mechanisms of Action: SERPINA1
Novel Mechanism: Yes
Modality: Nucleic Acid
Route of Administration: N/A
FDA Designation: None *
Approval Status: Not Approved
Approved Countries: None
Approved Indications: None
Known Adverse Events: None
Company: Korro Bio
Company Location:
Company CEO:
Additonal Commercial Interests: None
Clinical Description
![Map of Global Clinical Trials for KRRO-110](https://pryzm-maps.s3.us-west-2.amazonaws.com/666666current_maps.png)
Countries in Clinic:
Active Clinical Trial Count:
Highest Development Phases
Phase 0: alpha 1-Antitrypsin Deficiency
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