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AM E3-SG3249

Alternative Names: AM E3-SG3249, AME3-SG3249, AME3SG3249
Latest Update: 2024-05-01
Latest Update Note: Clinical Trial Update

Product Description

Potential first-in-class Antibody-Drug Conjugate (ADC) targeting CRLF2/TLSPR in “Ph-like” B-ALL (AM E3-SG3249) demonstrated significant preclinical efficacy, representing a pioneering approach to treating hematologic cancer characterized by poor prognosis and high relapse rates, often affecting adolescents. (Sourced from: https://www.irbm.com/press-releases/irbm-to-disclose-strong-antitumor-efficacy-of-novel-preclinical-agents-against-aggressive-brain-tumors-and-acute-lymphoblastic-leukemia-at-aacr/)

Mechanisms of Action: CRLF2 Inhibitor,TLSP Inhibitor

Novel Mechanism: Yes

Modality: Antibody Drug Conjugate

Route of Administration: N/A

FDA Designation: None *

Approval Status: Not Approved

Approved Countries: None

Approved Indications: None

Known Adverse Events: None

Company: IRBM
Company Location:
Company CEO:
Additonal Commercial Interests: None

Clinical Description

Map of Global Clinical Trials for AM E3-SG3249

Countries in Clinic:

Active Clinical Trial Count:

Highest Development Phases

Phase 0: Acute Lymphoid Leukemia

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